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Mouse Anti-ODC1 Recombinant Antibody (CBXO-0028) (CBMAB-O0311-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0028
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Ornithine Decarboxylase
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ornithine Decarboxylase 1
Introduction
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Entrez Gene ID
4953
UniProt ID
P11926
Alternative Names
Ornithine Decarboxylase 1; EC 4.1.1.17; ODC; Ornithine Decarboxylase
Function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Biological Process
Kidney developmentIEA:Ensembl
Polyamine metabolic processTAS:Reactome
Positive regulation of cell population proliferationIEA:Ensembl
Putrescine biosynthetic process from ornithineISS:UniProtKB
Regulation of protein catabolic processISS:UniProtKB
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
cytoplasm
cytosol
Involvement in disease
Bachmann-Bupp syndrome (BABS):
An autosomal dominant disorder characterized by global developmental delay, alopecia, absolute or relative macrocephaly, and facial dysmorphism. Neuroimaging shows white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.
PTM
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
More Infomation

Pérez-Rodríguez, F., Valdés-Santiago, L., García-Chávez, J. N., Castro-Guillén, J. L., & Ruiz-Herrera, J. (2023). Analysis of gene expression related to polyamine concentration and dimorphism induced in ornithine decarboxylase (odc) and spermidine synthase (spd) Ustilago maydis mutants. Fungal Genetics and Biology, 166, 103792.

Peng, V., Cao, S., Trsan, T., Bando, J. K., Avila-Pacheco, J., Cleveland, J. L., ... & Colonna, M. (2022). Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proceedings of the National Academy of Sciences, 119(45), e2214900119.

Miller, A. K., Tavera, G., Dominguez, R. L., Camargo, M. C., Waterboer, T., Wilson, K. T., ... & Morgan, D. R. (2021). Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Oncogene, 40(40), 5963-5969.

Zeng, Z., Lan, J., Lei, S., Yang, Y., He, Z., Xue, Y., & Chen, T. (2020). Simultaneous inhibition of ornithine decarboxylase 1 and pyruvate kinase M2 exerts synergistic effects against hepatocellular carcinoma cells. OncoTargets and therapy, 11697-11709.

Leon, K. E., Fruin, A. M., Nowotarski, S. L., & DiAngelo, J. R. (2020). The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila. Biochemical and Biophysical Research Communications, 523(2), 429-433.

Chai, X., Zhan, J., Pan, J., He, M., Li, B., Wang, J., ... & Liu, S. (2020). The rational discovery of multipurpose inhibitors of the ornithine decarboxylase. The FASEB Journal, 34(9), 10907-12921.

Hsieh, J. Y., Liu, Y. C., Cheng, I. T., Lee, C. J., Wang, Y. H., Fang, Y. S., ... & Hung, H. C. (2019). Critical factors in human antizymes that determine the differential binding, inhibition, and degradation of human ornithine decarboxylase. Biomolecules, 9(12), 864.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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