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Mouse Anti-NUP88 Recombinant Antibody (CBWJN-0293) (CBMAB-N4024-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0293
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nucleoporin 88
Introduction
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Entrez Gene ID
4927
UniProt ID
Q99567
Alternative Names
Nucleoporin 88; Nucleoporin 88kDa; Nucleoporin Nup88; Nuclear Pore Complex Protein Nup88; Nuclear Pore Complex Protein 88; 88 KDa Nucleoporin; Nucleoporin 88kD; Karyoporin;
Function
Component of nuclear pore complex.
Biological Process
Mitotic cell cycleIEA:Ensembl
mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Ribosomal large subunit export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Ribosomal small subunit export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nuclear pore complex
Involvement in disease
Fetal akinesia deformation sequence 4 (FADS4):
A clinically and genetically heterogeneous group of disorders with congenital malformations related to impaired fetal movement. Clinical features include fetal akinesia, intrauterine growth retardation, polyhydramnios, arthrogryposis, pulmonary hypoplasia, craniofacial abnormalities, and cryptorchidism. FADS4 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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