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Mouse Anti-NUDT6 Recombinant Antibody (9D12) (CBMAB-N3919-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9D12
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.37 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nudix Hydrolase 6
Introduction
This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
11162
UniProt ID
P53370
Alternative Names
Nudix Hydrolase 6; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6; Antisense Basic Fibroblast Growth Factor; FGF2AS; Nucleoside Diphosphate-Linked Moiety X Motif 6; Nudix Motif 6; Protein GFG;
Function
May contribute to the regulation of cell proliferation.
Biological Process
Negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Mitochondrion
Subcellular location may vary between isoforms.
More Infomation

Uzay, B., Bahadır‐Varol, A., Hökelekli, F. Ö., Yılmaz, M., Esen, E. C., Başar, K., ... & Eren‐Koçak, E. (2024). FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling. The Journal of Physiology.

Debar, L., Ishak, L., Moretton, A., Anoosheh, S., Morel, F., Jenninger, L., ... & Farge, G. (2023). NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities. Mitochondrion, 71, 93-103.

Winter, H., Winski, G., Busch, A., Chernogubova, E., Fasolo, F., Wu, Z., ... & Maegdefessel, L. (2023). Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression. Molecular Therapy, 31(6), 1775-1790.

Uzay, B., Hökelekli, F. Ö., Yılmaz, M., Esen, E. C., Başar, K., Bahadır-Varol, A., ... & Eren-Koçak, E. (2022). NUDT6, the Antisense Protein of FGF2 Gene, Plays a Depressogenic Role by Promoting Inflammation and Suppressing Neurogenesis without Altering FGF2 Signaling. bioRxiv, 2022-09.

Uzay, B., Belder, N., & Eren-Koçak, E. (2022). P614. The Role of NUDT6 and S100A9 as New Molecular Players in Hippocampus, Basolateral Amygdala and Prefrontal Cortex in a Post-Traumatic Stress Disorder (PTSD) Model. Biological Psychiatry, 91(9), S337-S338.

Winter, H., Jin, H., Chernogubova, E., Bäcklund, A., Winski, G., Pauli, J., ... & Maegdefessel, L. (2020). Therapeutic Benefit of Inhibiting the Long Non-coding RNA NUDT6 in Preclinical Models of Abdominal Aortic Aneurysm Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(Suppl_1), A168-A168.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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