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Mouse Anti-NSG1 Recombinant Antibody (1D22) (CBMAB-D2149-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D22
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
D4S234E (AAH01745, 1 a.a. ~ 185 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT EYEPDRKKGK ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL VVYKVYKYDR ACPDGFVLKN TQCIPEGLES YYAEQDSSAR EKFYTVINHY NLAKQSITRS VSPWMSVLSE EKLSEQETEA AEKSA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-185

Target

Full Name
neuron specific gene family member 1
Introduction
NSG1 plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. NSG1 regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. NSG1 is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome.
Entrez Gene ID
27065
UniProt ID
P42857
Alternative Names
Neuronal Vesicle Trafficking Associated 1; Neuron-Enriched Endosomal Protein Of 21 KDa; Neuron-Enriched Endosomal Protein Of 21 KD; Neuron-Specific Protein Family Member 1; Neuron Specific Gene Family Member 1; D4S234; NEEP21;
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity).
Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity).
In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).
Biological Process
Amyloid precursor protein metabolic processISS:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Clathrin coat assemblyManual Assertion Based On ExperimentIBA:GO_Central
Dopamine receptor signaling pathwayIEA:InterPro
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter receptor cycleISS:UniProtKB
Neurotransmitter receptor transport, endosome to postsynaptic membraneIEA:Ensembl
Positive regulation of receptor recyclingIEA:Ensembl
Postsynaptic neurotransmitter receptor cycleISS:UniProtKB
Receptor recyclingISS:UniProtKB
Regulation of long-term synaptic potentiationISS:UniProtKB
Spontaneous synaptic transmissionISS:UniProtKB
Vesicle-mediated transport in synapseIEA:Ensembl
Cellular Location
Membrane
Golgi apparatus, trans-Golgi network membrane
Endosome membrane
Cell projection, dendrite
Early endosome membrane
Late endosome membrane
Lysosome lumen
Recycling endosome membrane
Cytoplasmic vesicle membrane
Golgi apparatus, Golgi stack membrane
Endosome, multivesicular body membrane
Endoplasmic reticulum membrane
Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity).
Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942).
Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity).
Topology
Cytoplasmic: 1-82
Helical: 83-103
Lumenal: 104-185
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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