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Mouse Anti-NRTN Recombinant Antibody (CBWJN-0225) (CBMAB-N3631-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0225
Antibody Isotype
IgG2
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurturin
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]
Entrez Gene ID
4902
UniProt ID
Q99748
Alternative Names
Neurturin; Prepro-Neurturin; NTN;
Function
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Biological Process
MAPK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Nerve developmentIEA:Ensembl
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neural crest cell migrationManual Assertion Based On ExperimentIDA:MGI
Neuron projection developmentManual Assertion Based On ExperimentIDA:MGI
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Involvement in disease
Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
More Infomation

Chu, Y., & Kordower, J. H. (2023). Post‐Mortem Studies of Neurturin Gene Therapy for Parkinson's Disease: Two Subjects with 10 Years CERE120 Delivery. Movement Disorders, 38(9), 1728-1736.

Sato, S., Suzuki, Y., Kikuchi, M., Rikimaru, M., Saito, J., & Shibata, Y. (2023). Sputum Neurturin Levels in Adult Asthmatic Subjects. Journal of Asthma and Allergy, 889-901.

Wang, S., Nie, L., Song, Y., Zhang, F., Chen, X., Shi, W., ... & Gao, A. (2022). Neurturin promotes tumor cell motility and angiogenesis in colorectal cancer. Experimental Cell Research, 413(1), 113049.

Correia, J. C., Kelahmetoglu, Y., Jannig, P. R., Schweingruber, C., Shvaikovskaya, D., Zhengye, L., ... & Ruas, J. L. (2021). Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity. Cell Metabolism, 33(11), 2215-2230.

Jaumotte, J. D., Saarma, M., & Zigmond, M. J. (2021). Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. Plos one, 16(2), e0245663.

Connolly, E., Morgan, D. J., Franklin, M., Simpson, A., Shah, R., Brand, O. J., ... & Hussell, T. (2020). Neurturin regulates the lung-resident macrophage inflammatory response to viral infection. Life Science Alliance, 3(12).

Chu, Y., Bartus, R. T., Manfredsson, F. P., Olanow, C. W., & Kordower, J. H. (2020). Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease. Brain, 143(3), 960-975.

Gross, S. K., Shim, B. S., Bartus, R. T., Deaver, D., McEachin, Z., Bétourné, A., ... & Maragakis, N. J. (2020). Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery. Experimental Neurology, 323, 113091.

Vining, K. H., Lombaert, I. M. A., Patel, V. N., Kibbey, S. E., Pradhan-Bhatt, S., Witt, R. L., & Hoffman, M. P. (2019). Neurturin-containing laminin matrices support innervated branching epithelium from adult epithelial salispheres. Biomaterials, 216, 119245.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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