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Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1555) (CBMAB-N3621-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1555
Application
ELISA(Cap)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuropilin 2
Introduction
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8828
UniProt ID
O60462
Alternative Names
Neuropilin 2; Vascular Endothelial Cell Growth Factor 165 Receptor 2; VEGF165R2; Receptor For VEGF165 And Semaphorins Class3; Neuropilin-2a(17); Neuropilin-2a(22);
Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
Biological Process
Angiogenesis1 PublicationNAS:UniProtKB
Axon extension involved in axon guidanceISS:BHF-UCL
Axon guidanceManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion1 PublicationNAS:UniProtKB
Cellular response to leukemia inhibitory factorIEA:Ensembl
Dorsal root ganglion morphogenesisIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Facioacoustic ganglion developmentIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative chemotaxisIEA:Ensembl
Nerve developmentISS:BHF-UCL
Neural crest cell migration involved in autonomic nervous system developmentIEA:Ensembl
Outflow tract septum morphogenesisISS:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of postsynapse organizationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Sensory neuron axon guidanceIEA:Ensembl
Sympathetic ganglion developmentISS:BHF-UCL
Sympathetic neuron projection extensionISS:BHF-UCL
Sympathetic neuron projection guidanceISS:BHF-UCL
Trigeminal ganglion developmentIEA:Ensembl
Ventral trunk neural crest cell migrationIEA:Ensembl
Vestibulocochlear nerve structural organizationIEA:Ensembl
Cellular Location
Membrane
Isoform s9
Secreted
Topology
Extracellular: 21-864
Helical: 865-889
Cytoplasmic: 890-931
More Infomation

Immormino, R. M., Jania, C. M., Tilley, S. L., & Moran, T. P. (2022). Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model. Immunity, Inflammation and Disease, 10(3), e575.

Wang, J., Li, J., Yin, L., Pu, T., Wei, J., Karthikeyan, V., ... & Wu, B. J. (2022). Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer. Oncogene, 41(37), 4307-4317.

Lungulescu, C., Ghimpau, V., Gheonea, D. I., Sur, D., & Lungulescu, C. V. (2022). The Role of neuropilin-2 in the epithelial to mesenchymal transition of colorectal cancer: A systematic review. Biomedicines, 10(1), 172.

Islam, R., Mishra, J., Bodas, S., Bhattacharya, S., Batra, S. K., Dutta, S., & Datta, K. (2022). Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance. Cancer and Metastasis Reviews, 41(3), 771-787.

Dumond, A., Brachet, E., Durivault, J., Vial, V., Puszko, A. K., Lepelletier, Y., ... & Pagès, G. (2021). Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. Journal of experimental & clinical cancer research, 40, 1-18.

Dumond, A., & Pagès, G. (2021). Relevance of neuropilin 1 and neuropilin 2 targeting for cancer treatment. Journal of Cancer Immunology, 3(2), 111-114.

Lee, G., Kang, Y. E., Oh, C., Liu, L., Jin, Y., Lim, M. A., ... & Koo, B. S. (2020). Neuropilin-2 promotes growth and progression of papillary thyroid cancer cells. Auris Nasus Larynx, 47(5), 870-880.

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., ... & Muders, M. H. (2020). Neuropilin‐2 is an independent prognostic factor for shorter cancer‐specific survival in patients with acinar adenocarcinoma of the prostate. International journal of cancer, 146(9), 2619-2627.

Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging roles for neuropilin-2 in cardiovascular disease. International Journal of Molecular Sciences, 21(14), 5154.

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For research use only. Not intended for any clinical use.

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