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Mouse Anti-NRCAM Recombinant Antibody (S364-51) (CBMAB-N0521-WJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
S364-51
Antibody Isotype
IgG2a
Application
WB, ICC

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.1% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuronal Cell Adhesion Molecule
Introduction
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Mouse319504
Rat497815
UniProt ID
MouseQ810U4
RatP97686
Alternative Names
Neuronal Cell Adhesion Molecule; NgCAM-Related Cell Adhesion Molecule; Neuronal Surface Protein Bravo; Ng-CAM-Related; KIAA0343; Nr-CAM; HBravo;
Function
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Biological Process
AngiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Axonal fasciculation1 PublicationNAS:UniProtKB
Axonogenesis1 PublicationNAS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system development1 PublicationNAS:UniProtKB
Clustering of voltage-gated sodium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Neuron migration1 PublicationNAS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Positive regulation of neuron differentiation1 PublicationNAS:UniProtKB
Protein localizationIEA:Ensembl
Regulation of axon extension1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Regulation of postsynapse organizationIEA:Ensembl
Retinal ganglion cell axon guidanceIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Topology
Extracellular: 25-1167
Helical: 25-1167
Cytoplasmic: 1191-1304
More Infomation

He, L., Guo, H., Wang, H., Zhu, K., Li, D., Zhang, C., ... & Yang, J. J. (2024). Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain. Neurotherapeutics, 21(1), e00309.

Zhou, L., He, L., Liu, C. H., Qiu, H., Zheng, L., Sample, K. M., ... & Tang, H. (2023). Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 42(1), 311.

Sannes, A. C., Christensen, J. O., Nielsen, M. B., & Gjerstad, J. (2023). Stress-induced headache in the general working population is moderated by the NRCAM rs2300043 genotype. Scandinavian Journal of Pain, 23(2), 326-332.

Olsen, M. B., Sannes, A. C., Yang, K., Nielsen, M. B., Einarsen, S. V., Christensen, J. O., ... & Gjerstad, J. (2022). Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions. Iscience, 25(9).

Huang, F. J., Liu, Y. L., Wang, J., Zhou, Y. Y., Zhao, S. Y., & Qin, G. J. (2022). LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by regulating NrCAM transcription in Graves’ disease. Cell Cycle, 21(9), 921-933.

Moore, A., Chinnaiya, K., Kim, D. W., Brown, S., Stewart, I., Robins, S., ... & Placzek, M. (2022). Loss of Function of the neural cell adhesion molecule NrCAM regulates differentiation, proliferation and neurogenesis in early postnatal hypothalamic tanycytes. Frontiers in Neuroscience, 16, 832961.

Cheng, Y., Xie, L., Xu, Z., Hao, M., Yang, B., Shan, W., ... & Chen, X. (2022). NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB. Cancer Gene Therapy, 29(10), 1452-1462.

Liang, L., Wu, S., Lin, C., Chang, Y. J., & Tao, Y. X. (2020). Alternative splicing of Nrcam gene in dorsal root ganglion contributes to neuropathic pain. The Journal of Pain, 21(7-8), 892-904.

Mohan, V., Sullivan, C. S., Guo, J., Wade, S. D., Majumder, S., Agarwal, A., ... & Maness, P. F. (2019). Temporal regulation of dendritic spines through NrCAM-Semaphorin3F receptor signaling in developing cortical pyramidal neurons. Cerebral Cortex, 29(3), 963-977.

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For research use only. Not intended for any clinical use.

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