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Mouse Anti-NR4A2 Recombinant Antibody (3E4) (CBMAB-A6121-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
NR4A2 (AAH66890, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
nuclear receptor subfamily 4, group A, member 2
Introduction
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Entrez Gene ID
4929
UniProt ID
P43354
Alternative Names
HZF-3; NOT; NURR1; RNR1; TINUR
Function
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Biological Process
Adult locomotory behaviorIEA:Ensembl
Canonical Wnt signaling pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to extracellular stimulusManual Assertion Based On ExperimentIDA:MGI
Cellular response to oxidative stressIEA:Ensembl
Central nervous system neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system projection neuron axonogenesisIEA:Ensembl
Dopamine biosynthetic processIEA:Ensembl
Dopaminergic neuron differentiationISS:UniProtKB
Fat cell differentiationISS:UniProtKB
General adaptation syndromeIEA:Ensembl
Habenula developmentIEA:Ensembl
Midbrain dopaminergic neuron differentiationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Neuron maturationIEA:Ensembl
Neuron migrationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of catalytic activityIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Post-embryonic developmentIEA:Ensembl
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of respiratory gaseous exchangeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to amphetamineIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Signal transduction1 PublicationNAS:ProtInc
Transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Mostly nuclear; oxidative stress promotes cytoplasmic localization.
More Infomation

Zhao, S., Wang, X., Huang, F., Zhou, Y., Meng, D., Zhao, D., ... & Wang, Q. (2024). A role of NR4A2 in Graves’ disease: Regulation of Th17/Treg. Endocrine, 83(2), 432-441.

Vierbuchen, T., Agarwal, S., Johnson, J. L., Galia, L., Lei, X., Stein, K., ... & Fitzgerald, K. A. (2023). The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Proceedings of the National Academy of Sciences, 120(1), e2213715120.

Ashraf, S., Taegtmeyer, H., & Harmancey, R. (2022). Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice. Basic Research in Cardiology, 117(1), 33.

Song, X., Xu, W., Xiao, M., Lu, Y., Lan, X., Tang, X., ... & Wu, S. (2022). Two novel heterozygous truncating variants in NR4A2 identified in patients with neurodevelopmental disorder and brief literature review. Frontiers in Neuroscience, 16, 956429.

Català-Solsona, J., Miñano-Molina, A. J., & Rodríguez-Álvarez, J. (2021). Nr4a2 transcription factor in hippocampal synaptic plasticity, memory and cognitive dysfunction: a perspective review. Frontiers in Molecular Neuroscience, 14, 287.

Wirth, T., Mariani, L. L., Bergant, G., Baulac, M., Habert, M. O., Drouot, N., ... & Roze, E. (2020). Loss‐of‐function mutations in NR4A2 cause Dopa‐responsive dystonia parkinsonism. Movement Disorders, 35(5), 880-885.

Karki, K., Li, X., Jin, U. H., Mohankumar, K., Zarei, M., Michelhaugh, S. K., ... & Safe, S. (2020). Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. Journal of Neuro-oncology, 146, 25-39.

Jiang, L., Dai, S., Li, J., Liang, X., Qu, L., Chen, X., ... & Chen, Y. (2019). Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. Journal of Biological Chemistry, 294(51), 19795-19803.

Jakaria, M., Haque, M. E., Cho, D. Y., Azam, S., Kim, I. S., & Choi, D. K. (2019). Molecular insights into NR4A2 (Nurr1): an emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death. Molecular neurobiology, 56, 5799-5814.

Moon, M., Jung, E. S., Jeon, S. G., Cha, M. Y., Jang, Y., Kim, W., ... & Kim, K. S. (2019). Nurr1 (NR4A2) regulates Alzheimer’s disease‐related pathogenesis and cognitive function in the 5XFAD mouse model. Aging cell, 18(1), e12866.

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For research use only. Not intended for any clinical use.

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