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Mouse Anti-NR2F6 Recombinant Antibody (CBFYE-1570) (CBMAB-E2224-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1570
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human NR2F6 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Subfamily 2 Group F Member 6
Introduction
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Entrez Gene ID
2063
UniProt ID
P10588
Alternative Names
Nuclear Receptor Subfamily 2 Group F Member 6; V-ErbA-Related Protein 2; ERBAL2; EAR-2; EAR2; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 2; Nuclear Receptor Subfamily 2, Group F, Member 6; Nuclear Receptor V-ErbA-Related; ERBA-Related Gene-2
Function
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Detection of temperature stimulus involved in sensory perception of painIEA:Ensembl
Entrainment of circadian clock by photoperiodIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Neuron developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
More Infomation

Zhou, W. Y., Liu, P., Xia, Y. F., Shi, Y. J., Xu, H. Y., Ding, M., ... & Liu, Y. (2024). NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis. Molecular Metabolism, 101891.

Kim, H., Feng, Y., Murad, R., Pozniak, J., Pelz, C., Chen, Y., ... & Ronai, Z. E. A. (2023). Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Science Advances, 9(27), eadf6621.

Chen, Y., & Chen, L. (2022). The expression and biological effect of NR2F6 in non-small cell lung cancer. Frontiers in Oncology, 12, 940234.

Olson, W. J., Jakic, B., Labi, V., Woelk, J., Derudder, E., Baier, G., & Hermann-Kleiter, N. (2022). A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis. Frontiers in Immunology, 13, 845235.

Klepsch, V., Siegmund, K., & Baier, G. (2021). Emerging next-generation target for cancer immunotherapy research: the orphan nuclear receptor NR2F6. Cancers, 13(11), 2600.

Zhou, B., Jia, L., Zhang, Z., Xiang, L., Yuan, Y., Zheng, P., ... & Lu, Y. (2020). The nuclear orphan receptor NR2F6 promotes hepatic steatosis through upregulation of fatty acid transporter CD36. Advanced Science, 7(21), 2002273.

Klapper, L., Ribbat-Idel, J., Kuppler, P., Paulsen, F. O., Bruchhage, K. L., Rades, D., ... & Perner, S. (2020). NR2F6 as a Prognostic Biomarker in HNSCC. International journal of molecular sciences, 21(15), 5527.

Klepsch, V., Pommermayr, M., Humer, D., Brigo, N., Hermann-Kleiter, N., & Baier, G. (2020). Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy. Cell Communication and Signaling, 18, 1-12.

Wang, L., Long, H., Zheng, Q., Bo, X., Xiao, X., & Li, B. (2019). Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Molecular cancer, 18(1), 1-12.

Olson, W. J., Jakic, B., Labi, V., Schoeler, K., Kind, M., Klepsch, V., ... & Hermann-Kleiter, N. (2019). Orphan nuclear receptor NR2F6 suppresses T follicular helper cell accumulation through regulation of IL-21. Cell reports, 28(11), 2878-2891.

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For research use only. Not intended for any clinical use.

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