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Mouse Anti-NPR3 Recombinant Antibody (2B12) (CBMAB-N3251-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B12
Antibody Isotype
IgG2a
Application
FC, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.72 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Natriuretic Peptide Receptor 3
Introduction
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Entrez Gene ID
4883
UniProt ID
P17342
Alternative Names
Natriuretic Peptide Receptor 3; Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C); Atrial Natriuretic Peptide Clearance Receptor; Atrial Natriuretic Peptide Receptor Type C; Atrionatriuretic Peptide Receptor C; Guanylate Cyclase C; C5orf23; ANPR-C; ANPRC;
Function
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of adenylate cyclase activityIEA:Ensembl
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Osteoclast proliferationISS:UniProtKB
Pancreatic juice secretionIEA:Ensembl
Phosphatidylinositol-mediated signalingIEA:Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Positive regulation of nitric-oxide synthase activityISS:BHF-UCL
Positive regulation of urine volumeISS:UniProtKB
Regulation of blood pressureISS:UniProtKB
Regulation of osteoblast proliferationISS:UniProtKB
Skeletal system developmentISS:UniProtKB
VasodilationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 27-481
Helical: 482-504
Cytoplasmic: 505-541
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For research use only. Not intended for any clinical use.

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