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Rabbit Anti-NGF Recombinant Antibody (BA0014) (CBMAB-0518CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0014
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Synthetic peptide from residues near the N-terminus of human NGF-beta precursor (pro-NGF)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nerve Growth Factor
Introduction
Nerve growth factor is a polypeptide involved in the regulation of growth and differentiation of sympathetic and certain sensory neurons. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
Entrez Gene ID
Human4803
Mouse18049
Rat310738
UniProt ID
HumanP01138
MouseP01139
RatP25427
Alternative Names
NGFB; HSAN5; Beta-NGF
Function
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020).
Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity).
Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processIGI:ARUK-UCL
Extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ARUK-UCL
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Neuron apoptotic processIGI:ARUK-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIDA:MGI
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of collateral sproutingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of DNA bindingBy SimilarityISS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron differentiationManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of Ras protein signal transductionISS:ParkinsonsUK-UCL
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Endosome lumen
ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 5 (HSAN5):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
More Infomation

Santucci, D., Racca, A., & Alleva, E. (2021). When nerve growth factor met behavior. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 205-214.

Maranesi, M., Boiti, C., & Zerani, M. (2021). Nerve growth factor (NGF) and animal reproduction. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 277-287.

Mitra, S., Gera, R., Linderoth, B., Lind, G., Wahlberg, L., Almqvist, P., ... & Eriksdotter, M. (2021). A review of techniques for biodelivery of nerve growth factor (NGF) to the brain in relation to Alzheimer’s disease. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 167-191.

Oo, W. M., & Hunter, D. J. (2021). Nerve growth factor (NGF) inhibitors and related agents for chronic musculoskeletal pain: a comprehensive review. BioDrugs, 35, 611-641.

Zha, K., Yang, Y., Tian, G., Sun, Z., Yang, Z., Li, X., ... & Guo, Q. (2021). Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies. Stem cells translational medicine, 10(7), 1008-1020.

Wise, B. L., Seidel, M. F., & Lane, N. E. (2021). The evolution of nerve growth factor inhibition in clinical medicine. Nature Reviews Rheumatology, 17(1), 34-46.

Barker, P. A., Mantyh, P., Arendt-Nielsen, L., Viktrup, L., & Tive, L. (2020). Nerve growth factor signaling and its contribution to pain. Journal of pain research, 1223-1241.

Ciafrè, S., Ferraguti, G., Tirassa, P., Iannitelli, A., Ralli, M., Greco, A., ... & Fiore, M. (2020). Nerve growth factor in the psychiatric brain. Rivista di psichiatria, 55(1), 4-15.

Li, R., Li, D., Wu, C., Ye, L., Wu, Y., Yuan, Y., ... & Xiao, J. (2020). Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics, 10(4), 1649.

Naletova, I., Satriano, C., Pietropaolo, A., Gianì, F., Pandini, G., Triaca, V., ... & Rizzarelli, E. (2019). The copper (II)-assisted connection between NGF and BDNF by means of nerve growth factor-mimicking short peptides. Cells, 8(4), 301.

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For research use only. Not intended for any clinical use.

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