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Mouse Anti-Nes Recombinant Antibody (CBMAB-0635-LY)


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Summary

Host Animal
Mouse
Specificity
Rat, Mouse
Antibody Isotype
IgM
Application
IF, IHC, WB

Basic Information

Specificity
Rat, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nestin
Introduction
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Entrez Gene ID
Mouse18008
Rat25491
UniProt ID
MouseQ6P5H2
RatP21263
Alternative Names
Nestin; Nbla00170;
Function
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
Biological Process
Brain development Source: UniProtKB
Cell projection morphogenesis Source: Ensembl
Central nervous system development Source: UniProtKB
Embryonic camera-type eye development Source: UniProtKB
G2/M transition of mitotic cell cycle Source: DFLAT
Negative regulation of catalytic activity Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of protein binding Source: UniProtKB
Positive regulation of intermediate filament depolymerization Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Stem cell proliferation Source: DFLAT
Cellular Location
Cytoskeleton
intermediate filament
intermediate filament cytoskeleton
Other locations
cytoplasm
PTM
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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