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Rabbit Anti-NEO1 Recombinant Antibody (BA0143) (CBMAB-0508CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0143
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Human Neogenin aa 950-1100
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neogenin 1
Introduction
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. By fluorescence in situ hybridization (FISH), Meyerhardt et al. (1997) localized NGN in 15q22, a region infrequently affected by alterations in cancer. Vielmetter et al. (1997) mapped NEO1 to 15q22.3-q23 by FISH. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. Rajagopalan et al. (2004) presented evidence that neogenin functions as a receptor for repulsive guidance molecule, or RGM (RGMA; 607362). Like Rgm, neogenin was expressed in a gradient across the embryonic chicken retina. The avoidance of Rgm by chicken temporal retinal axons was blocked by anti-neogenin antibody and the soluble neogenin ectodomain. Dorsal root ganglion axons were unresponsive to Rgm, but were converted to a responsive state by neogenin expression.
Entrez Gene ID
4756
UniProt ID
Q92859
Alternative Names
NGN; IGDCC2; NTN1R2
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Biological Process
Axon guidance Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Iron ion homeostasis Source: MGI
Neuron migration Source: GO_Central
Positive regulation of BMP signaling pathway Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 34-1105
Helical: 1106-1126
Cytoplasmic: 1127-1461
More Infomation

Hu, X., Li, L., Li, F., Yang, Y., An, J., Zhou, X., ... & Xu, Y. (2023). Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling. Cell Death Discovery, 9(1), 47.

Zhang, J., Xu, Y., Wei, C., Yin, Z., Pan, W., Zhao, M., ... & Wang, M. (2023). Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling. Cellular and Molecular Life Sciences, 80(11), 324.

Li, N., Liu, H., Xue, Y., Chen, J., Kong, X., & Zhang, Y. (2022). Upregulation of neogenin-1 by a CREB1-BAF47 complex in vascular endothelial cells is implicated in atherogenesis. Frontiers in Cell and Developmental Biology, 10, 803029.

Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., ... & Trumpp, A. (2021). Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nature communications, 12(1), 608.

Villanueva, A. A., Sanchez-Gomez, P., Muñoz-Palma, E., Puvogel, S., Casas, B. S., Arriagada, C., ... & Palma, V. (2021). The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. Cell Adhesion & Migration, 15(1), 58-73.

Ren, X., Yao, L. L., Pan, J. X., Zhang, J. S., Mei, L., Wang, Y. G., & Xiong, W. C. (2021). Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease–like vasculopathy. Neurobiology of Disease, 154, 105339.

Yao, L. L., Hu, J. X., Li, Q., Lee, D., Ren, X., Zhang, J. S., ... & Xiong, W. C. (2020). Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex. The Journal of clinical investigation, 130(12), 6490-6509.

Lin, S., Liu, W., Chen, C. L., Sun, D., Hu, J. X., Li, L., ... & Xiong, W. C. (2020). Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation. Journal of Molecular Cell Biology, 12(1), 17-31.

Gulati, G. S., Zukowska, M., Noh, J. J., Zhang, A., Wesche, D. J., Sinha, R., ... & Szade, K. (2019). Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells. Proceedings of the National Academy of Sciences, 116(50), 25115-25125.

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For research use only. Not intended for any clinical use.

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