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Mouse Anti-NACC1 Antibody (1A1) (CBMAB-0697-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A1
Antibody Isotype
IgG2a
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nucleus Accumbens Associated 1
Introduction
NACC1 (nucleus accumbens-associated protein 1) is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. NACC1 suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer.
Entrez Gene ID
112939
UniProt ID
Q96RE7
Alternative Names
NAC1; BEND8; NAC-1; BTBD30; BTBD14B
Function
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Biological Process
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Distribution in the cytoplasm is dependent on phosphorylation.
Involvement in disease
Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination (NECFM):
A neurodevelopmental disorder characterized by microcephaly, profound developmental delay, intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements. Brain imaging reveals delayed myelination and cerebral atrophy.
More Infomation

Xie, Q., Tong, C., & Xiong, X. (2023). An overview of the co-transcription factor NACC1: Beyond its pro-tumor effects. Life Sciences, 122314.

Daniel, J. A., Elizarova, S., Shaib, A. H., Chouaib, A. A., Magnussen, H. M., Wang, J., ... & Tirard, M. (2023). An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission. Frontiers in Molecular Neuroscience, 16.

Ye, X., Song, H., Hu, H., Zhou, C., Chen, Q., Hong, L., ... & Zhu, H. (2022). MiR-361-3p alleviates cerebral ischemia–reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway. Journal of Molecular Histology, 53(2), 357-367.

Cao, Z., Chen, H., Mei, X., & Li, X. (2021). Silencing of NACC1 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells via regulating the AKT/mTOR signaling pathway. Oncology Letters, 22(6), 1-8.

Argani, P., Palsgrove, D. N., Anders, R. A., Smith, S. C., Saoud, C., Kwon, R., ... & Antonescu, C. R. (2021). A novel NIPBL-NACC1 gene fusion is characteristic of the cholangioblastic variant of intrahepatic cholangiocarcinoma. The American journal of surgical pathology, 45(11), 1550-1560.

Yang, T., Shen, P., Chen, Q., Wu, P., Yuan, H., Ge, W., ... & Jiang, K. (2021). FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. Journal of Experimental & Clinical Cancer Research, 40(1), 1-25.

Tao, H. F., Shen, J. X., Hou, Z. W., Chen, S. Y., Su, Y. Z., & Fang, J. L. (2021). lncRNA FOXP4‑AS1 predicts poor prognosis and accelerates the progression of mantle cell lymphoma through the miR‑423‑5p/NACC1 pathway. Oncology Reports, 45(2), 469-480.

Sun, Z. (2020). Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling. Life Sciences, 259, 118157.

Li, L., Yu, H., & Ren, Q. (2020). MiR-218-5p suppresses the progression of retinoblastoma through targeting NACC1 and inhibiting the AKT/mTOR signaling pathway. Cancer Management and Research, 6959-6967.

Yin, L., Sun, T., & Liu, R. (2020). NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760. Acta Biochimica et Biophysica Sinica, 52(3), 302-309.

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For research use only. Not intended for any clinical use.

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