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Mouse Anti-NAALAD2 Recombinant Antibody (CBWJN-1149) (CBMAB-N1018-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1149
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-acetylated alpha-linked acidic dipeptidase 2
Introduction
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Entrez Gene ID
10003
UniProt ID
Q9Y3Q0
Alternative Names
N-Acetylated Alpha-Linked Acidic Dipeptidase 2; Glutamate Carboxypeptidase III; NAALADase II; EC 3.4.17.21; GCPIII; N-Acetylated Alpha-Linked Acidic Dipeptidase II;
Function
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
Biological Process
Proteolysis Source: UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-7
Helical: 8-31
Extracellular: 32-740
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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