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Mouse Anti-MYH14 Recombinant Antibody (CBFYM-2927) (CBMAB-M3122-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog, Rat, Rabbit
Clone
CBFYM-2927
Antibody Isotype
IgG1
Application
IHC-Fr, IHC-P

Basic Information

Immunogen
Myosin isolated from rabbit skeletal muscle
Specificity
Human, Mouse, Dog, Rat, Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Myosin Heavy Chain 14
Introduction
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human79784
Mouse71960
Rat308572
Dog100688336
UniProt ID
HumanQ7Z406
MouseQ6URW6
RatF1LNF0
DogA0A5F4D5L6
Alternative Names
Myosin Heavy Chain 14; Myosin, Heavy Chain 14, Non-Muscle; Myosin Heavy Chain, Non-Muscle IIc; Non-Muscle Myosin Heavy Chain IIc; Myosin, Heavy Polypeptide 14; NMHC II-C; Nonmuscle Myosin Heavy Chain II-C; MYH14 Variant Protein; NMHC-II-C; Myosin-14
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Biological Process
Actin filament-based movement Source: Ensembl
Actomyosin structure organization Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Neuronal action potential Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Skeletal muscle contraction Source: UniProtKB
Skeletal muscle tissue development Source: UniProtKB
Vocalization behavior Source: UniProtKB
Cellular Location
Cytoskeleton
actomyosin
myosin II complex
stress fiber
Cytosol
Extracellular region
extracellular exosome
Other locations
brush border
growth cone
membrane
myosin II filament
Involvement in disease
Deafness, autosomal dominant, 4A (DFNA4A):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH):
A complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
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For research use only. Not intended for any clinical use.

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