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Mouse Anti-MS4A1 Recombinant Antibody (CB363A) (CBMAB-CA363LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CB363A
Antibody Isotype
IgG
Application
ELISA, IHC

Basic Information

Immunogen
Synthetic Peptide
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Membrane Spanning 4-Domains A1
Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human931
Mouse12482
Rat309217
UniProt ID
HumanP11836
MouseP19437
RatD4A4Y3
Alternative Names
Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1;
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111).

Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Biological Process
B cell activation Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Calcium ion import into cytosol Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Humoral immune response Source: UniProtKB
Protein tetramerization Source: UniProtKB
Response to bacterium Source: Ensembl
Store-operated calcium entry Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Note: Constitutively associated with membrane rafts.
Involvement in disease
Immunodeficiency, common variable, 5 (CVID5):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Cytoplasmic: 1-56
Helical: 57-78
Extracellular: 79-84
Helical: 85-105
Cytoplasmic: 106-120
Helical: 121-141
Extracellular: 142-188
Helical: 189-209
Cytoplasmic: 210-297
PTM
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
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For research use only. Not intended for any clinical use.

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