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Mouse Anti-MRC1 Recombinant Antibody (CBFYM-0146) (CBMAB-M0167-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Horse, Human
Clone
CBFYM-0146
Antibody Isotype
IgG1
Application
WB, IHC-Fr, FC, Inhib, IHC, IF

Basic Information

Specificity
Mouse, Horse, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mannose Receptor C-Type 1
Introduction
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.
Entrez Gene ID
Human4360
Mouse17533
Horse100068247
UniProt ID
HumanP22897
MouseQ61830
HorseA0A3Q2KKM2
Alternative Names
Mannose Receptor C-Type 1; Macrophage Mannose Receptor 1-Like Protein 1; C-Type Lectin Domain Family 13 Member D; Mannose Receptor, C Type 1-Like 1; Human Mannose Receptor; CLEC13DL; CLEC13D; MRC1L1; MMR
Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Biological Process
Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Receptor-mediated endocytosis Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Endosome
Endosome membrane
Topology
Extracellular: 19-1389
Helical: 1390-1410
Cytoplasmic: 1411-1456
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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