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Mouse Anti-MINA Recombinant Antibody (4B1) (CBMAB-0755-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B1
Antibody Isotype
IgG2a
Application
ELISA, MA

Basic Information

Immunogen
Recombinant full length protein of MINA
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYC-induced nuclear antigen
Introduction
MINA is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. This protein is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression.
Entrez Gene ID
84864
UniProt ID
Q8IUF8
Alternative Names
ROX; MDIG; NO52; MINA53
Function
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Biological Process
Histone H3-K36 demethylation Source: GO_Central
Histone H3-K4 demethylation Source: GO_Central
Ribosome biogenesis Source: UniProtKB-KW
Cellular Location
Nucleus
Nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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