Mouse Anti-METAP1 Recombinant Antibody (CBFYM-2108) (CBMAB-M2290-FY)

Name: Mouse Anti-METAP1 Recombinant Antibody (CBFYM-2108)
SKU: CBMAB-M2290-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

CBFYM-2108

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

METHIONYL AMINOPEPTIDASE 1

Introduction

METAP1 is a Protein Coding gene. Among its related pathways are Phototransduction and Signaling by GPCR. Gene Ontology annotations related to this gene include hydrolase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1D.

Entrez Gene ID

Human	23173
Mouse	75624
Rat	295500

UniProt ID

Human	P53582
Mouse	Q8BP48
Rat	D3ZE72

Alternative Names

Methionyl Aminopeptidase 1; Peptidase M 1; MetAP 1; MAP 1; Methionine Aminopeptidase 1; EC 3.4.11.18

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Biological Process

N-terminal protein amino acid modification Source: HGNC-UCL
Peptidyl-methionine modification Source: HGNC-UCL
Platelet aggregation Source: UniProtKB
Protein initiator methionine removal Source: UniProtKB-UniRule
Regulation of translation Source: HGNC-UCL

Cellular Location

Cytoplasm

More Infomation

References

Soens, R., & Cantor, J. (2022). Investigating the conditionally essential role of human METAP1. The FASEB Journal, 36.

Caglayan, A. O., Aktar, F., Bilguvar, K., Baranoski, J. F., Akgumus, G. T., Harmanci, A. S., ... & Gunel, M. (2021). METAP1 mutation is a novel candidate for autosomal recessive intellectual disability. Journal of human genetics, 66(2), 215-218.

Tumskiy, R. S., Tumskaia, A. V., Pylaev, T. E., Avdeeva, E. S., & Evstigneeva, S. S. (2021). Docking and antibacterial activity of novel nontoxic 5-arylidenepyrimidine-triones as inhibitors of NDM-1 and MetAP-1. Future Medicinal Chemistry, 13(12), 1041-1055.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-METAP1 Recombinant Antibody (CBFYM-0626)

Mouse Anti-METAP1 Recombinant Antibody (CBFYM-0096)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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