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Mouse Anti-MEIS1 (AA 176-390 ) Recombinant Antibody (CBFYM-2041) (CBMAB-M2221-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2041
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 176-390 of human MEIS1(NP_002389) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 176-390

Target

Full Name
MEIS HOMEOBOX 1
Introduction
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE family of homeodomain-containing proteins.
Entrez Gene ID
4211
UniProt ID
O00470
Alternative Names
Meis Homeobox 1; Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse); Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog; Leukemogenic Homolog Protein; Homeobox Protein Meis1; Meis1 (Mouse) Homolog; WUGSC:H_NH0444B04.1
Function
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Biological Process
Angiogenesis Source: GO_Central
Animal organ morphogenesis Source: GO_Central
Brain development Source: GO_Central
Definitive hemopoiesis Source: Ensembl
Embryonic pattern specification Source: GO_Central
Eye development Source: GO_Central
Hemopoiesis Source: GO_Central
Lens morphogenesis in camera-type eye Source: Ensembl
Locomotory behavior Source: Ensembl
Megakaryocyte development Source: Ensembl
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of neuron differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Restless legs syndrome 7 (RLS7):
A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.
More Infomation

Coulombe, P., Cole, G., Fentiman, A., Parker, J. D., Yung, E., Bilenky, M., ... & Karsan, A. (2023). Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression. Nature Communications, 14(1), 4537.

Xiang, P., Yang, X., Escano, L., Dhillon, I., Schneider, E., Clemans-Gibbon, J., ... & Rouhi, A. (2022). Elucidating the importance and regulation of key enhancers for human MEIS1 expression. Leukemia, 36(8), 1980-1989.

Yao, M., Gu, Y., Yang, Z., Zhong, K., & Chen, Z. (2021). MEIS1 and its potential as a cancer therapeutic target. International Journal of Molecular Medicine, 48(3), 1-9.

Jiang, M., Xu, S., Bai, M., & Zhang, A. (2021). The emerging role of MEIS1 in cell proliferation and differentiation. American Journal of Physiology-Cell Physiology, 320(3), C264-C269.

Walker, A. R., Byrd, J. C., Blachly, J. S., Bhatnagar, B., Mims, A. S., Orwick, S., ... & Blum, W. G. (2020). Entospletinib in combination with induction chemotherapy in previously untreated acute myeloid leukemia: response and predictive significance of HOXA9 and MEIS1 expression. Clinical Cancer Research, 26(22), 5852-5859.

Whitlock, N. C., Trostel, S. Y., Wilkinson, S., Terrigino, N. T., Hennigan, S. T., Lake, R., ... & Sowalsky, A. G. (2020). MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Oncogene, 39(34), 5663-5674.

Salminen, A. V., Lam, D. D., & Winkelmann, J. (2019). Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice. Advances in Pharmacology, 84, 175-184.

Johng, D., Torga, G., Ewing, C. M., Jin, K., Norris, J. D., McDonnell, D. P., & Isaacs, W. B. (2019). HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate, 79(4), 414-424.

Sarayloo, F., Dion, P. A., & Rouleau, G. A. (2019). MEIS1 and restless legs syndrome: a comprehensive review. Frontiers in neurology, 10, 935.

Lindgren, I. M., Drake, R. R., Chattergoon, N. N., & Thornburg, K. L. (2019). Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. The FASEB Journal, 33(6), 7417.

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For research use only. Not intended for any clinical use.

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