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Rabbit Anti-MC4R Recombinant Antibody (CBFYM-1850) (CBMAB-M2018-FY)


See all MC4R antibodies
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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBFYM-1850
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MELANOCORTIN 4 RECEPTOR
Introduction
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
Entrez Gene ID
Human4160
Mouse17202
Rat25635
UniProt ID
HumanP32245
MouseP56450
RatP70596
Alternative Names
Melanocortin 4 Receptor; MC4-R; Melanocortin Receptor 4
Function
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Diet induced thermogenesis Source: Ensembl
Energy reserve metabolic process Source: Ensembl
Feeding behavior Source: ProtInc
Insulin secretion Source: Ensembl
Negative regulation of feeding behavior Source: Ensembl
Positive regulation of bone resorption Source: HGNC-UCL
Regulation of eating behavior Source: ARUK-UCL
Regulation of grooming behavior Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to insulin Source: Ensembl
Response to melanocyte-stimulating hormone Source: ARUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Obesity (OBESITY):
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Topology
Extracellular: 1-43
Helical: 44-69
Cytoplasmic: 70-81
Helical: 82-106
Extracellular: 107-123
Helical: 124-145
Cytoplasmic: 146-165
Helical: 166-186
Extracellular: 187-191
Helical: 192-215
Cytoplasmic: 216-248
Helical: 249-271
Extracellular: 272-280
Helical: 281-304
Cytoplasmic: 305-332
More Infomation

Seelig, E., Henning, E., Keogh, J. M., Gillett, D., Shin, E., Buscombe, J., ... & Farooqi, I. S. (2022). Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying. Clinical endocrinology, 96(2), 270-275.

Fatima, M. T., Ahmed, I., Fakhro, K. A., & Akil, A. S. A. S. (2022). Melanocortin‐4 receptor complexity in energy homeostasis, obesity and drug development strategies. Diabetes, Obesity and Metabolism, 24(4), 583-598.

Zhang, H., Chen, L. N., Yang, D., Mao, C., Shen, Q., Feng, W., ... & Zhang, Y. (2021). Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research, 31(11), 1163-1175.

Zhang, J., Li, J., Wu, C., Hu, Z., An, L., Wan, Y., ... & Wang, Y. (2020). The Asp298Asn polymorphism of melanocortin‐4 receptor (MC4R) in pigs: evidence for its potential effects on MC4R constitutive activity and cell surface expression. Animal Genetics, 51(5), 694-706.

Hainer, V., Hainerová, I. A., Kunešová, M., Braunerová, R. T., Zamrazilova, H., & Bendlová, B. (2020). Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R). Physiological Research, 69(Suppl 2), S245.

Kleinau, G., Heyder, N. A., Tao, Y. X., & Scheerer, P. (2020). Structural complexity and plasticity of signaling regulation at the melanocortin-4 receptor. International Journal of Molecular Sciences, 21(16), 5728.

Yu, J., Gimenez, L. E., Hernandez, C. C., Wu, Y., Wein, A. H., Han, G. W., ... & Stevens, R. C. (2020). Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. Science, 368(6489), 428-433.

Sharma, S., Garfield, A. S., Shah, B., Kleyn, P., Ichetovkin, I., Moeller, I. H., ... & Van der Ploeg, L. H. (2019). Current mechanistic and pharmacodynamic understanding of melanocortin-4 receptor activation. Molecules, 24(10), 1892.

Kühnen, P., Krude, H., & Biebermann, H. (2019). Melanocortin-4 receptor signalling: importance for weight regulation and obesity treatment. Trends in molecular medicine, 25(2), 136-148.

Heyder, N., Kleinau, G., Szczepek, M., Kwiatkowski, D., Speck, D., Soletto, L., ... & Scheerer, P. (2019). Signal transduction and pathogenic modifications at the melanocortin-4 receptor: A structural perspective. Frontiers in endocrinology, 10, 515.

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For research use only. Not intended for any clinical use.

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