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Mouse Anti-MAPK13 Recombinant Antibody (12B2) (CBMAB-P0487-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog, Monkey
Clone
12B2
Antibody Isotype
IgG2b
Application
WB, IHC, IF

Basic Information

Specificity
Human, Mouse, Dog, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase 13
Introduction
MAPK13 is a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene.
Entrez Gene ID
Human5603
Mouse26415
Dog612821
Monkey719085
UniProt ID
HumanO15264
MouseQ9Z1B7
DogE2RKA7
MonkeyA0A1D5QC76
Alternative Names
Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase P38 Delta; Stress-Activated Protein Kinase 4; MAP Kinase P38 Delta; MAP Kinase 13; EC 2.7.11.24; MAPK 13;
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Biological Process
Cell cycleIEA:UniProtKB-KW
Cellular response to anisomycinManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to sodium arseniteManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to sorbitolManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to UVManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Response to osmotic stressManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Cytosol
Nucleus
PTM
Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
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For research use only. Not intended for any clinical use.

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