MAPK13 Matched Antibody Pair (716) (APMAB-716LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-MAPK13 monoclonal antibody, 100 ug

Detection Antibody

Anti-MAPK13 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Alternative Names

Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase P38 Delta; Stress-Activated Protein Kinase 4; MAP Kinase P38 Delta; MAP Kinase 13; EC 2.7.11.24; MAPK 13;

Entrez Gene ID

5603

UniProt ID

O15264

More Infomation

References

Keeler, S. P., Wu, K., Zhang, Y., Mao, D., Li, M., Iberg, C. A., ... & Holtzman, M. J. (2023). A new MAPK13-guided inhibitor for respiratory inflammation and mucus production. bioRxiv, 2023-05.

Keeler, S. P., Wu, K., Zhang, Y., Mao, D., Li, M., Iberg, C. A., ... & Holtzman, M. J. (2023). A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production. American Journal of Physiology-Lung Cellular and Molecular Physiology, 325(6), L726-L740.

Kim, J., Chun, Y., Ramirez, C. B., Hoffner, L. A., Jung, S., Jang, K. H., ... & Lee, G. (2023). MAPK13 stabilization via m6A mRNA modification limits anticancer efficacy of rapamycin. Journal of Biological Chemistry, 299(9).

Kim, J., Chun, Y., Ramirez, C. B., Hoffner, L. A., Jung, S., Jang, K. H., ... & Lee, G. (2022). MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin. bioRxiv, 2022-08.

Liu, Y., Chang, Y., & Cai, Y. (2020). circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis. Aging (Albany NY), 12(8), 6774.

Zheng, L., Han, X., Hu, Y., Zhao, X., Yin, L., Xu, L., ... & Peng, J. (2019). Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis. Pharmacological Research, 139, 431-439.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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