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Mouse Anti-MAP4K3 Recombinant Antibody (A997) (CBMAB-AP11664LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A997
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
A synthetic Peptide of human MAP4K3
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3
Introduction
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Entrez Gene ID
8491
UniProt ID
Q8IVH8
Alternative Names
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3; Germinal Center Kinase-Related Protein Kinase; MAPK/ERK Kinase Kinase Kinase 3; MEK Kinase Kinase 3; EC 2.7.11.1; RAB8IPL1; MEKKK 3;
Function
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Biological Process
Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
JNK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to tumor necrosis factorManual Assertion Based On ExperimentIDA:UniProtKB
Response to UVManual Assertion Based On ExperimentIDA:UniProtKB
More Infomation

Chuang, H. C., Hung, W. T., Chen, Y. M., Hsu, P. M., Yen, J. H., Lan, J. L., & Tan, T. H. (2022). Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 81(2), 243-254.

Becker-Greene, D., Li, H., Perez-Cremades, D., Wu, W., Bestepe, F., Ozdemir, D., ... & Icli, B. (2021). MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Cellular and Molecular Life Sciences, 78, 7663-7679.

Li, J., Yan, L., Luo, J., Tong, L., Gao, Y., Feng, W., ... & Sun, Z. (2021). Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3. Biomedicine & Pharmacotherapy, 133, 110965.

Shi, Y., Mo, X., Hong, S., Li, T., Chen, B., & Chen, G. (2020). Studying the role and molecular mechanisms of MAP4K3 in sorafenib resistance of hepatocellular carcinoma. BioMed Research International, 2020.

Wang, Z., Han, Z., Zhang, L., Zhang, S., & Wang, B. (2019). MicroRNA‑98‑5p regulates the proliferation and apoptosis of A549 cells by targeting MAP4K3. Oncology Letters, 18(4), 4288-4293.

Chuang, H. C., & Tan, T. H. (2019). MAP4K3/GLK in autoimmune disease, cancer and aging. Journal of Biomedical Science, 26, 1-8.

Chuang, H. C., Chang, C. C., Teng, C. F., Hsueh, C. H., Chiu, L. L., Hsu, P. M., ... & Tan, T. H. (2019). MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Research, 79(19), 4978-4993.

Liu, F., Yin, R., Chen, X., Chen, W., Qian, Y., Zhao, Y., ... & Zhang, Y. (2019). Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma. Biomedicine & Pharmacotherapy, 114, 108605.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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