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Rat Anti-MAGI2 Recombinant Antibody (13F10) (CBMAB-M0001-WJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
13F10
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant corresponding to full length AIP1 expressed in E coli.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 2
Introduction
MAGI2 is a protein-coding gene encodes the protein interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. Diseases associated with MAGI2 include Nephrotic Syndrome 15 and Chromosome 1P36 Deletion Syndrome. An important paralog of this gene is MAGI1.
Entrez Gene ID
50791
UniProt ID
Q9WVQ1
Alternative Names
AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1
Function
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Biological Process
Cellular response to nerve growth factor stimulusISS:UniProtKB
Glomerular visceral epithelial cell developmentISS:UniProtKB
Negative regulation of activin receptor signaling pathwayISS:UniProtKB
Negative regulation of cell migrationISS:UniProtKB
Negative regulation of cell population proliferationISS:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Nerve growth factor signaling pathwayISS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Planar cell polarity pathway involved in axis elongation1 PublicationNAS:UniProtKB
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:UniProtKB
Receptor clusteringISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionISS:UniProtKB
Cellular Location
Cytoplasm
Late endosome
Cell junction, synapse, synaptosome
Cell membrane By Similarity; Peripheral membrane protein
Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).
Involvement in disease
Nephrotic syndrome 15 (NPHS15):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. NPHS15 is an autosomal recessive form with onset in the first months of life. Disease severity is variable. Some patients show rapid progression to end-stage renal failure.
More Infomation

Xu, Z., Chen, Z., Peng, M., Zhang, Z., Luo, W., Shi, R., ... & Hong, Y. (2022). MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3. Bioengineered, 13(2), 2673-2685.

Xu, X., Yuan, X., Ni, J., Guo, J., Gao, Y., Yin, W., ... & Zhang, J. (2021). MAGI2‐AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2. Journal of cellular physiology, 236(2), 1116-1130.

Kai-Xin, L., Cheng, C., Rui, L., Zheng-Wei, S., Wen-Wen, T., & Peng, X. (2021). Roles of lncRNA MAGI2-AS3 in human cancers. Biomedicine & Pharmacotherapy, 141, 111812.

Xue, C., Li, G., Lu, J., Luo, J., & Jia, J. (2021). Novel insights for lncRNA MAGI2-AS3 in solid tumors. Biomedicine & Pharmacotherapy, 137, 111429.

Yamada, H., Shirata, N., Makino, S., Miyake, T., Trejo, J. A. O., Yamamoto-Nonaka, K., ... & Asanuma, K. (2021). MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes. Kidney International, 99(2), 382-395.

Zhang, J., & Wang, R. (2021). Deregulated lncRNA MAGI2-AS3 in Alzheimer's disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p. Experimental Gerontology, 144, 111180.

Li, D., Wang, J., Zhang, M., Hu, X., She, J., Qiu, X., ... & Qin, S. (2020). LncRNA MAGI2-AS3 is regulated by BRD4 and promotes gastric cancer progression via maintaining ZEB1 overexpression by sponging miR-141/200a. Molecular Therapy-Nucleic Acids, 19, 109-123.

Ren, H., Li, Z., Tang, Z., Li, J., & Lang, X. (2020). Long noncoding MAGI2‐AS3 promotes colorectal cancer progression through regulating miR‐3163/TMEM106B axis. Journal of cellular physiology, 235(5), 4824-4833.

Yin, Z., Ma, T., Yan, J., Shi, N., Zhang, C., Lu, X., ... & Jian, Z. (2019). LncRNA MAGI2‐AS3 inhibits hepatocellular carcinoma cell proliferation and migration by targeting the miR‐374b‐5p/SMG1 signaling pathway. Journal of cellular physiology, 234(10), 18825-18836.

Pu, J., Wang, J., Wei, H., Lu, T., Wu, X., Wu, Y., ... & Lu, Y. (2019). lncRNA MAGI2-AS3 prevents the development of HCC via recruiting KDM1A and promoting H3K4me2 demethylation of the RACGAP1 promoter. Molecular Therapy-Nucleic Acids, 18, 351-362.

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For research use only. Not intended for any clinical use.

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