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Mouse Anti-LY6K Recombinant Antibody (CBYJL-2210) (CBMAB-L2443-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2210
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lymphocyte antigen 6 family member K
Introduction
Diseases associated with LY6K include Cyclothymic Disorder. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.
Entrez Gene ID
54742
UniProt ID
Q17RY6
Alternative Names
CT97; ly-6K; URLC10; HSJ001348; lymphocyte antigen 6K; cancer/testis antigen 97; lymphocyte antigen 6 complex, locus K; up-regulated in lung cancer 10
Function
Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity).
May play a role in cell growth (PubMed:18089789).
Biological Process
Binding of sperm to zona pellucidaManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cytoplasm
Cell membrane
Cytoplasmic vesicle, secretory vesicle, acrosome
Membrane raft
More Infomation

Park, S., Park, D., Han, S., Chung, G. E., Soh, S., Ka, H. I., ... & Yang, Y. (2023). LY6K depletion modulates TGF‐β and EGF signaling. Cancer Medicine.

Selvanesan, B. C., Varghese, S., Andrys-Olek, J., Arriaza, R. H., Prakash, R., Tiwari, P. B., ... & Upadhyay, G. (2023). Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Letters, 558, 216094.

Guo, D., Liu, Y., Jiang, Y., Zheng, S., Xu, T., Zhu, J., ... & Zhang, Y. (2022). A narrative review of the emerging role of lymphocyte antigen 6 complex locus K in cancer: from basic research to clinical practice. Annals of Translational Medicine, 10(1).

Geng, L., Wang, Z., & Tian, Y. (2022). Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K. Journal of Ovarian Research, 15(1), 1-15.

Sastry, N. G., Wan, X., Huang, T., Alvarez, A. A., Pangeni, R. P., Song, X., ... & Cheng, S. Y. (2020). LY6K promotes glioblastoma tumorigenicity via CAV-1–mediated ERK1/2 signaling enhancement. Neuro-oncology, 22(9), 1315-1326.

Benti, S., Tiwari, P. B., Goodlett, D. W., Daneshian, L., Kern, G. B., Smith, M. D., ... & Upadhyay, G. (2020). Small molecule binds with lymphocyte antigen 6K to induce cancer cell death. Cancers, 12(2), 509.

Son, D., Kong, H. K., Kim, Y., Song, M. J., Kim, H. P., Lee, H. W., & Park, J. H. (2019). Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncology Letters, 17(1), 379-387.

Upadhyay, G. (2019). Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. Frontiers in immunology, 10, 819.

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For research use only. Not intended for any clinical use.

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