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Mouse Anti-LSP1 Recombinant Antibody (A943) (CBMAB-AP4315LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A943
Antibody Isotype
IgG1, κ
Application
IHC, IP, WB

Basic Information

Immunogen
Tonsil cells
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lymphocyte-specific protein 1
Entrez Gene ID
4046
UniProt ID
P33241
Function
May play a role in mediating neutrophil activation and chemotaxis.
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-7IEA:Ensembl
ChemotaxisIEA:Ensembl
Signal transductionIEA:InterPro
Cellular Location
Cell membrane
PTM
Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).
More Infomation

Hilchey, S. P., Palshikar, M. G., Mendelson, E. S., Shen, S., Rasam, S., Emo, J. A., ... & Zand, M. S. (2022). Cyclosporine A modulates LSP1 protein levels in Human B cells to attenuate B cell migration at low O2 Levels. Life, 12(8), 1284.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Le, N. P. K., do Nascimento, A. F., Schneberger, D., Quach, C. C., Zhang, X., Aulakh, G. K., ... & Singh, B. (2022). Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model. Respiratory Research, 23(1), 1-16.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Chen, J., Xiao, Q., Li, X., Liu, R., Long, X., Liu, Z., ... & Li, Y. (2022). The correlation of leukocyte-specific protein 1 (LSP1) rs3817198 (T> C) polymorphism with breast cancer: A meta-analysis. Medicine, 101(45).

Koral, K., Bhushan, B., Stoops, J., Orr, A., Mars, W., & Michalopoulos, G. (2020). Lymphocyte Specific Protein‐1 suppresses TCPOBOP induced hepatocellular proliferation. The FASEB Journal, 34(S1), 1-1.

Cao, J. Y., Guo, Q., Guan, G. F., Zhu, C., Zou, C. Y., Zhang, L. Y., ... & Li, G. Y. (2020). Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma. Aging (Albany NY), 12(2), 1656.

Kwon, R., Hong, B. K., Lee, K. G., Choi, E., Sabbagh, L., Cho, C. S., ... & Kim, W. U. (2020). Regulation of tumor growth by leukocyte-specific protein 1 in T cells. Journal for Immunotherapy of Cancer, 8(2).

Kulkarni, R., Jiang, S., Birrane, G., & Prasad, A. (2020). Lymphocyte‐specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST‐2)‐mediated intracellular trafficking of HIV‐1 in dendritic cells. FEBS letters, 594(12), 1947-1959.

Smeir, M. (2019). Leukocyte specific protein-1 modulates expression and activity of endothelial nitric oxide synthase (Doctoral dissertation, University of Saskatchewan).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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