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Mouse Anti-LSAMP Recombinant Antibody (2G9) (CBMAB-0138-CN)


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Summary

Host Animal
Mouse
Specificity
Rat, Cattle, Cat, Fish, Human, Mouse
Clone
2G9
Antibody Isotype
IgG2a
Application
Blocking, IF, IHC, IP, WB

Basic Information

Immunogen
Adult Rat hippocampal crude membrane preparation
Specificity
Rat, Cattle, Cat, Fish, Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSAMP
Introduction
This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Entrez Gene ID
Human4045
Mouse268890
Rat29561
Cattle100336456
Cat101093883
Zebrafish664692
UniProt ID
HumanQ13449
MouseQ8BLK3
RatQ62813
CattleA0A3Q1MYV4
CatA0A337SES8
ZebrafishQ2EGT7
Alternative Names
MGC105298
Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
More Infomation

Xu, X., Gong, C., Wang, Y., Yin, Z., Wang, X., Hu, Y., & Fang, Z. (2023). Bioinformatics analysis and experimental validation identified HMGA2/microRNA-200c-3p/LSAMP/Wnt axis as an immunological factor of patients with colorectal cancer. American Journal of Cancer Research, 13(9), 3898.

Martinez-Monleon, A., Gaarder, J., Djos, A., Kogner, P., & Fransson, S. (2023). Identification of recurrent 3q13. 31 chromosomal rearrangement indicates LSAMP as a tumor suppressor gene in neuroblastoma. International Journal of Oncology, 62(2), 1-11.

Gong, W., Li, Y., Xian, J., Yang, L., Wang, Y., Zhang, X., ... & Qiu, F. (2022). Long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis. Cancer Cell International, 22(1), 1-16.

Morgan, D. L., Callais, V. E., Acevedo, M., & Davis, K. B. (2021, August). A potential canary in the coal mine: A critical policy analysis of the Illinois LSAMP during the COVID-19 pandemic. In Frontiers in Education (Vol. 6, p. 668394). Frontiers Media SA.

Preuss, M., Merriweather, S., Avila, J., Butler-Purry, K., Watson, K., Walton, S., ... & Texas A&M University System Louis Stokes Alliance for Minority Participation. (2021, July). The Impacts of Global Research and International Educational Experiences on Texas A&M University System LSAMP Participants. In Frontiers in Education (Vol. 6, p. 674772). Frontiers Media SA.

Chang, C. Y., Wu, K. L., Chang, Y. Y., Liu, Y. W., Huang, Y. C., Jian, S. F., ... & Hsu, Y. L. (2021). The downregulation of LSAMP expression promotes lung cancer progression and is associated with poor survival prognosis. Journal of Personalized Medicine, 11(6), 578.

San Miguel, C., & Gates, A. E. (2021, November). Synergistic Interaction of LSAMP Alliances to Improve the Graduation and Transfer of Community College Students in New Jersey United States. In Frontiers in Education (Vol. 6, p. 679865). Frontiers.

Bregin, A., Kaare, M., Jagomäe, T., Karis, K., Singh, K., Laugus, K., ... & Vasar, E. (2020). Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacology Biochemistry and Behavior, 198, 173017.

Hua, X., Liu, Z., Zhou, M., Tian, Y., Zhao, P. P., Pan, W. H., ... & Yu, L. N. (2019). RETRACTED: LSAMP-AS1 binds to microRNA-183–5p to suppress the progression of prostate cancer by up-regulating the tumor suppressor DCN.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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