Mouse Anti-LRRN1 Recombinant Antibody (CBYJL-2048) (CBMAB-L2170-YJ)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-2048

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

LRRN1 (CAL37408.1, 1 a.a. ~ 716 a.a) full-length recombinant protein with GST tag.Immunogen sequence: MARMSFVIAACQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK LVKVPQLALQ KVPSLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV YFAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA DTKPTQVDTS RSYYMW.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-716

Target

Full Name

leucine rich repeat neuronal 1

Introduction

An important paralog of this gene is LRRN3.

Entrez Gene ID

57633

UniProt ID

Q6UXK5

Alternative Names

NLRR-1; FIGLER3; leucine-rich repeat neuronal protein 1; fibronectin type III, immunoglobulin and leucine rich repeat domains 3; neuronal leucine-rich repeat protein 1

Biological Process

Positive regulation of synapse assemblyIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 26-631
Helical: 632-652
Cytoplasmic: 653-716

More Infomation

References

Maunsell, H. R., Ellis, K., Kelley, M. W., & Driver, E. C. (2023). Lrrn1 regulates medial boundary formation in the developing mouse organ of Corti. Journal of Neuroscience, 43(29), 5305-5318.

Antikainen, A. A., Haukka, J. K., Kumar, A., Syreeni, A., Hägg-Holmberg, S., Ylinen, A., ... & Sandholm, N. (2022). Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes. medRxiv, 2022-11.

Zhang, Y., Liu, Q., Yang, S., & Liao, Q. (2021). Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma. Molecular Therapy-Oncolytics, 23, 51-64.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-LRRN1 Recombinant Antibody (3D11)

Mouse Anti-LRRN1 Recombinant Antibody (3F1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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