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Rabbit Anti-LRRK2 (phospho S973) Recombinant Antibody (MJF-R12 (37-1)) (CBMAB-0452CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
MJF-R12 (37-1)
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human LRRK2 (internal sequence) (phospho S973)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Human prostate-specific antigen (APS) is a kallikrein-like protease present in seminal plasma. It is a single-chain glycoprotein with a molecular mass of about 33 kD that may function normally in the liquefaction of seminal coagulum. Radioimmunoassay of serum levels of this antigen (called PSA in the clinical setting) is useful in the diagnosis and monitoring of prostatic carcinoma. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Entrez Gene ID
120892
UniProt ID
Q5S007
Alternative Names
PARK8; RIPK7; ROCO2; AURA17; DARDARIN
More Infomation

Taymans, J. M., Fell, M., Greenamyre, T., Hirst, W. D., Mamais, A., Padmanabhan, S., ... & Thaler, A. (2023). Perspective on the current state of the LRRK2 field. npj Parkinson's Disease, 9(1), 104.

Marchand, A., Drouyer, M., Sarchione, A., Chartier-Harlin, M. C., & Taymans, J. M. (2020). LRRK2 phosphorylation, more than an epiphenomenon. Frontiers in neuroscience, 14, 527.

Watanabe, R., Buschauer, R., Böhning, J., Audagnotto, M., Lasker, K., Lu, T. W., ... & Villa, E. (2020). The in situ structure of Parkinson’s disease-linked LRRK2. Cell, 182(6), 1508-1518.

Jeong, G. R., & Lee, B. D. (2020). Pathological functions of LRRK2 in Parkinson’s disease. Cells, 9(12), 2565.

Tolosa, E., Vila, M., Klein, C., & Rascol, O. (2020). LRRK2 in Parkinson disease: challenges of clinical trials. Nature Reviews Neurology, 16(2), 97-107.

Deniston, C. K., Salogiannis, J., Mathea, S., Snead, D. M., Lahiri, I., Matyszewski, M., ... & Leschziner, A. E. (2020). Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction. Nature, 588(7837), 344-349.

Berwick, D. C., Heaton, G. R., Azeggagh, S., & Harvey, K. (2019). LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same. Molecular neurodegeneration, 14(1), 1-22.

Harvey, K., & Outeiro, T. F. (2019). The role of LRRK2 in cell signalling. Biochemical Society Transactions, 47(1), 197-207.

Kluss, J. H., Mamais, A., & Cookson, M. R. (2019). LRRK2 links genetic and sporadic Parkinson's disease. Biochemical Society Transactions, 47(2), 651-661.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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