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Mouse Anti-LRRK1 Recombinant Antibody (3G8) (CBMAB-A5077-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G8
Antibody Isotype
IgG1, κ
Application
IF, ELISA

Basic Information

Immunogen
LRRK1 (AAH05408, 560 a.a. ~ 659 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
leucine-rich repeat kinase 1
Entrez Gene ID
79705
UniProt ID
Q38SD2
Alternative Names
FLJ23119; FLJ27465; KIAA1790; RIPK6; Roco1
Biological Process
Bone resorptionIEA:Ensembl
Negative regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Osteoclast developmentIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of intracellular signal transductionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
More Infomation

Reimer, J. M., Dickey, A. M., Lin, Y. X., Abrisch, R. G., Mathea, S., Chatterjee, D., ... & Leschziner, A. E. (2023). Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature Structural & Molecular Biology, 1-11.

Hanafusa, H., Fujita, K., Kamio, M., Iida, S., Tamura, Y., Hisamoto, N., & Matsumoto, K. (2023). LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER–endosome contact site. Journal of Cell Science, 136(6), jcs260566.

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., ... & Alessi, D. R. (2022). PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. Biochemical Journal, 479(18), 1941-1965.

Fujita, K., Kedashiro, S., Yagi, T., Hisamoto, N., Matsumoto, K., & Hanafusa, H. (2022). The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation. Journal of Cell Science, 135(23), jcs260395.

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., ... & Alessi, D. R. (2021). Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Biochemical Journal, 478(3), 553-578.

Li, S., Guo, W., Geng, H., Wang, C., Yang, S., & Xu, X. (2020). LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis. Bioscience Reports, 40(5), BSR20193631.

Howaldt, A., Hennig, A. F., Rolvien, T., Rössler, U., Stelzer, N., Knaus, A., ... & Kornak, U. (2020). Adult osteosclerotic metaphyseal dysplasia with progressive osteonecrosis of the jaws and abnormal bone resorption pattern due to a LRRK1 splice site mutation. Journal of Bone and Mineral Research, 35(7), 1322-1332.

Hanafusa, H., Yagi, T., Ikeda, H., Hisamoto, N., Nishioka, T., Kaibuchi, K., ... & Matsumoto, K. (2019). LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP. Journal of cell science, 132(11), jcs228809.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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