Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-LRRFIP1 Recombinant Antibody (CBYJT-1421) (CBMAB-T0445-YJ)


See all LRRFIP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1421
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LRRFIP1
Introduction
LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. It may control smooth muscle cells proliferation following artery injury through PDGFA repression. It may also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Entrez Gene ID
9208
UniProt ID
Q32MZ4
Alternative Names
GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm
More Infomation

Chen, W., Zhao, W., Hao, M., & Wang, Y. (2023). lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation. Open Medicine, 18(1), 20230738.

Wen, Y., Wang, E., Wang, X., Qing, S., Chaogetu, B., Wang, C., ... & Huang, Y. (2023). Copy number variations of LRRFIP1 gene and the relationship with growth traits in four Chinese sheep. Animal Biotechnology, 34(7), 3008-3015.

Ma, W., Bao, Z., Qian, Z., Zhang, K., Fan, W., Xu, J., ... & Jiang, T. (2022). LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma. CNS Neuroscience & Therapeutics, 28(6), 873-883.

Kawasaki, S., Ohtsuka, H., Sato, Y., Douchi, D., Sato, M., Ariake, K., ... & Unno, M. (2021). Silencing of LRRFIP1 enhances the sensitivity of gemcitabine in pancreatic cancer cells by activating JNK/c-Jun signaling. Pancreatology, 21(4), 771-778.

Liu, W., Duan, Q., Gong, L., Yang, Y., Huang, Z., Guo, H., & Niu, X. (2021). A novel LRRFIP1-ALK fusion in inflammatory myofibroblastic tumor of hip and response to crizotinib. Investigational New Drugs, 39, 278-282.

Yao, Y., Xu, K., Sun, Y., Tian, T., Shen, W., Sun, F., ... & Lei, M. (2020). MiR-215-5p inhibits the inflammation injury in septic H9c2 by regulating ILF3 and LRRFIP1. International Immunopharmacology, 78, 106000.

DeGregorio-Rocasolano, N., Guirao, V., Ponce, J., Melià-Sorolla, M., Aliena-Valero, A., García-Serran, A., ... & Gasull, T. (2020). Comparative proteomics unveils LRRFIP1 as a new player in the DAPK1 interactome of neurons exposed to oxygen and glucose deprivation. Antioxidants, 9(12), 1202.

Yin, X., Liu, P., Liu, Y. Y., Liu, M. Y., Fan, W. L., Liu, B. Y., & Zhao, J. H. (2019). LRRFIP1 expression triggers platelet agglutination by enhancing αIIbβ3 expression. Experimental and Therapeutic Medicine, 18(1), 269-277.

Takimoto, M. (2019). Multidisciplinary roles of LRRFIP1/GCF2 in human biological systems and diseases. Cells, 8(2), 108.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LRRFIP1 Recombinant Antibody (CBYJT-1421)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry