Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-LPO Recombinant Antibody (CBYJL-1937) (CBMAB-L1993-YJ)


See all LPO antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1937
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, ELISA

Basic Information

Immunogen
The antibody is a mouse monoclonal antibody raised against LPO. It has been selected for its ability to recognize LPO in immunohistochemical staining and WBting.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LPO
Introduction
LPO is a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. LPO is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Entrez Gene ID
4025
UniProt ID
P22079
Alternative Names
SPO; lactoperoxidase; salivary peroxidase; EC 1.11.1.7
Function
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity).
May contribute to airway host defense against infection.
Biological Process
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of chemical stimulus involved in sensory perception of bitter tasteManual Assertion Based On ExperimentIDA:UniProtKB
Hydrogen peroxide catabolic processIEA:UniProtKB-KW
Response to oxidative stress1 PublicationNAS:UniProtKB
Cellular Location
Secreted
More Infomation

Yamakaze, J., & Lu, Z. (2021). Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Scientific Reports, 11(1), 12429.

Welk, A., Patjek, S., Gärtner, M., Baguhl, R., Schwahn, C., & Below, H. (2021). Antibacterial and antiplaque efficacy of a lactoperoxidase-thiocyanate-hydrogen-peroxide-system-containing lozenge. BMC microbiology, 21, 1-12.

Viswanathan, V., Rani, C., Ahmad, N., Singh, P. K., Sharma, P., Kaur, P., ... & Singh, T. P. (2021). Structure of yak lactoperoxidase at 1.55 Å resolution. The Protein Journal, 40, 8-18.

Buys, E. M., & Seifu, E. (2021). Enzymes indigenous to milk: Lactoperoxidase. Elsevier.

El-Fakharany, E. M. (2021). Nanoformulation approach for improved stability and efficiency of lactoperoxidase. Preparative Biochemistry & Biotechnology, 51(7), 629-641.

Al-Shehri, S. S., Duley, J. A., & Bansal, N. (2020). Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles. Redox biology, 34, 101524.

Kalin, R., Koksal, Z., Kalin, P., Karaman, M., Gulcin, İ., & Ozdemir, H. (2020). In vitro effects of standard antioxidants on lactoperoxidase enzyme–A molecular docking approach. Journal of Biochemical and Molecular Toxicology, 34(1), e22421.

Köksal, Z., & Alim, Z. (2020). Lactoperoxidase, an antimicrobial enzyme, is inhibited by some indazoles. Drug and chemical toxicology, 43(1), 22-26.

Magacz, M., Kędziora, K., Sapa, J., & Krzyściak, W. (2019). The significance of lactoperoxidase system in oral health: Application and efficacy in oral hygiene products. International journal of molecular sciences, 20(6), 1443.

Al-Baarri, A. N. M., Damayanti, N. T., Legowo, A. M., Tekiner, İ. H., & Hayakawa, S. (2019). Enhanced antibacterial activity of lactoperoxidase–thiocyanate–hydrogen peroxide system in reduced-lactose milk whey. International Journal of Food Science, 2019.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LPO Recombinant Antibody (CBYJL-1937)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry