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Mouse Anti-LMO2 Recombinant Antibody (CBYJL-1870) (CBMAB-L1859-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1870
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIM domain only 2
Introduction
LIM domain only 2 is a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and essential role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. It has been found that alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
4005
UniProt ID
P25791
Alternative Names
TTG2; LMO-2; RBTN2; RHOM2; RBTNL1
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Biological Process
Cellular response to thyroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
More Infomation

Park, C. G., Choi, S. H., Lee, S. Y., Eun, K., Park, M. G., Jang, J., ... & Kim, H. (2022). Cytoplasmic LMO2-LDB1 complex activates STAT3 signaling through interaction with gp130-JAK in glioma stem cells. Cells, 11(13), 2031.

Chapman, J., Verdun, R. E., & Lossos, I. S. (2021). Low LIM-domain only 2 (LMO2) expression in aggressive B cell lymphoma correlates with MYC and MYC/BCL2 rearrangements, especially in germinal center cell-type tumors. Leukemia & lymphoma, 62(10), 2547-2550.

Brar, N., Butzmann, A., Kumar, J., Peerani, R., Morgan, E. A., Grigoriadis, G., ... & Ohgami, R. S. (2020). LIM domain only 2 (LMO2) expression distinguishes T‐lymphoblastic leukemia/lymphoma from indolent T‐lymphoblastic proliferations. Histopathology, 77(6), 984-988.

Wang, W., Chen, Y., Chang, Y., & Sun, W. (2020). Biochemical feature of LMO2 interactome and LMO2 function prospect. Medical science monitor basic research, 26, e924421-1.

Li, L., Mitra, A., Zhao, B., Choi, S., Lee, J., Stamos, D., ... & Dave, U. (2019). LIM Domain Protein 1 (Ldb1) Is Required for Lmo2 Oncogene-Induced Thymocyte Self-Renewal and T-Cell Leukemia in a Mouse Model of Human T-ALL.

Morishima, T., Krahl, A. C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., ... & Skokowa, J. (2019). LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. Blood, The Journal of the American Society of Hematology, 134(14), 1159-1175.

Miyashita, K., Kitajima, K., Goyama, S., Kitamura, T., & Hara, T. (2018). Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochemical and biophysical research communications, 495(3), 2310-2316.

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For research use only. Not intended for any clinical use.

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