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Mouse Anti-LLGL2 Recombinant Antibody (CBYJL-1796) (CBMAB-L1736-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1796
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 101-199 from human LLGL2 (NP_004515) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 101-199

Target

Full Name
LLGL2
Introduction
Diseases associated with LLGL2 include Retinitis Pigmentosa 24. Among its related pathways are Actin Nucleation by ARP-WASP Complex and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include PDZ domain binding. An important paralog of this gene is LLGL1.Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex functions in the initial phase of the establishment of epithelial cell polarity.
Entrez Gene ID
3993
UniProt ID
Q6P1M3
Alternative Names
LLGL2
Function
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
Biological Process
Cell divisionIEA:UniProtKB-KW
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity1 PublicationIC:ComplexPortal
ExocytosisIEA:UniProtKB-KW
Leucine transportManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
PTM
Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.
More Infomation

Gu, Q. Y., Liu, Y. X., Wang, J. L., Huang, X. L., Li, R. N., & Linghu, H. (2023). LLGL2 Inhibits Ovarian Cancer Metastasis by Regulating Cytoskeleton Remodeling via ACTN1. Cancers, 15(24), 5880.

Bii, V. M., Rudoy, D., Klezovitch, O., & Vasioukhin, V. (2023). Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis. bioRxiv, 2023-03.

Zhang, W., Wang, M., Liu, L. T., Cui, D., Liu, M., & Liu, D. G. (2023). Differential expression of LLGL2 in prostate ductal adenocarcinoma and acinar adenocarcinoma and its significance. Zhonghua Bing li xue za zhi= Chinese Journal of Pathology, 52(10), 1012-1016.

Zhang, S., Chen, Y., Hu, Q., Zhao, T., Wang, Z., Zhou, Y., ... & Liu, K. (2022). SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p. Cancer Biology & Therapy, 23(1), 1-15.

Hisada, T., Kondo, N., Wanifuchi-Endo, Y., Osaga, S., Fujita, T., Asano, T., ... & Toyama, T. (2022). Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer. Scientific Reports, 12(1), 16515.

Kim, K. H., Hong, G. L., Kim, Y. J., Lee, H. J., & Jung, J. Y. (2022). Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy. Biomedicines, 10(8), 1981.

Leng, S., Xie, F., Liu, J., Shen, J., Quan, G., & Wen, T. (2021). LLGL2 Increases Ca2+ influx and exerts oncogenic activities via PI3K/AKT signaling pathway in hepatocellular carcinoma. Frontiers in Oncology, 11, 683629.

Hisada, T., Kondo, N., Endo, Y., Asano, T., Uemoto, Y., Nishikawa, S., ... & Toyama, T. (2020). Abstract P6-04-11: LLGL2 is involved in resistance to tamoxifen in estrogen receptor-alpha positive breast cancer patients. Cancer Research, 80(4_Supplement), P6-04.

Saito, Y., Li, L., Coyaud, E., Luna, A., Sander, C., Raught, B., ... & Muthuswamy, S. K. (2019). LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature, 569(7755), 275-279.

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For research use only. Not intended for any clinical use.

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