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Mouse Anti-LIN7C Recombinant Antibody (11A2) (CBMAB-0704-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
11A2
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein of LIN7C
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIN7C
Introduction
Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. This protein plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains.
Entrez Gene ID
55327
UniProt ID
Q9NUP9
Alternative Names
MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
Function
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Biological Process
ExocytosisIEA:UniProtKB-KW
Maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Morphogenesis of an epithelial sheetManual Assertion Based On ExperimentIMP:UniProtKB
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to basolateral plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Cellular Location
Cell membrane
Basolateral cell membrane
Cell junction
Cell junction, synapse, postsynaptic density membrane
Cell junction, tight junction
Mainly basolateral in renal epithelial cells.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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