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Mouse Anti-LGALS3BP Recombinant Antibody (3D6) (CBMAB-L1292-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D6
Antibody Isotype
IgG2a
Application
FC, IF, IHC, WB

Basic Information

Immunogen
LGALS3BP antibody was raised in mouse using a human recombinant protein fragment corresponding to amino acids 19-300 of human LGALS3BP (NP_005558) produced in E. coli as the immunogen.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 19-300

Target

Full Name
LGALS3BP
Introduction
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be involved in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.Diseases associated with LGALS3BP include Ostertagiasis and Trichostrongyloidiasis.Among its related pathways are Response to elevated platelet cytosolic Ca2+.
Entrez Gene ID
3959
UniProt ID
Q08380
Alternative Names
90K; BTBD17B; CyCAP; M2BP; MAC-2-BP; TANGO10B; gp90
Function
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Secreted, extracellular space, extracellular matrix
More Infomation

Zhao, C., Liu, Y., Meng, J., Wang, X., Liu, X., Li, W., ... & Hou, S. (2022). Lgals3bp in Microglia Promotes Retinal Angiogenesis through Pi3k/Akt Pathway During Hypoxia. Investigative Ophthalmology & Visual Science, 63(8), 25-25.

Song, Y., Wang, M., Tong, H., Tan, Y., Hu, X., Wang, K., & Wan, X. (2021). Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression. Oncogene, 40(3), 633-646.

Kyrousi, C., O’neill, A. C., Brazovskaja, A., He, Z., Kielkowski, P., Coquand, L., ... & Cappello, S. (2021). Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity. Nature Communications, 12(1), 6298.

Luo, M., Zhang, Q., Hu, Y., Sun, C., Sheng, Y., & Deng, C. (2021). Lgals3bp: A potential plasma biomarker associated with diagnosis and prognosis in patients with sepsis. Infection and Drug Resistance, 2863-2871.

Cho, S. H., Shim, H. J., Park, M. R., Choi, J. N., Akanda, M. R., Hwang, J. E., ... & Chung, I. J. (2021). Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling. Cell death discovery, 7(1), 65.

Costa, J., Pronto-Laborinho, A., Pinto, S., Gromicho, M., Bonucci, S., Tranfield, E., ... & de Carvalho, M. (2020). Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. Scientific reports, 10(1), 5649.

Kimura, R., Yoshimaru, T., Matsushita, Y., Matsuo, T., Ono, M., Park, J. H., ... & Katagiri, T. (2020). The GALNT6‑LGALS3BP axis promotes breast cancer cell growth. International Journal of Oncology, 56(2), 581-595.

Zhang, X., Ding, H., Lu, Z., Ding, L., Song, Y., Jing, Y., ... & Ni, Y. (2019). Increased LGALS3BP promotes proliferation and migration of oral squamous cell carcinoma via PI3K/AKT pathway. Cellular Signalling, 63, 109359.

Xu, G., Xia, Z., Deng, F., Liu, L., Wang, Q., Yu, Y., ... & Liu, S. (2019). Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS pathogens, 15(8), e1008002.

Lodermeyer, V., Ssebyatika, G., Passos, V., Ponnurangam, A., Malassa, A., Ewald, E., ... & Goffinet, C. (2018). The antiviral activity of the cellular glycoprotein LGALS3BP/90K is species specific. Journal of virology, 92(14), 10-1128.

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For research use only. Not intended for any clinical use.

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