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Mouse Anti-LAYN Recombinant Antibody (3F7D7E2) (CBMAB-L0746-YJ)

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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F7D7E2
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Human cell-derived rhLayilin extracellular domain.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
layilin
Introduction
Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. LAYN is an important paralog of this gene is CHODL. Receptor for hyaluronate.
Entrez Gene ID
UniProt ID
Function
Receptor for hyaluronate.
Cellular Location
Membrane
Colocalizes with TLN1 at the membrane ruffles.
Topology
Extracellular: 22-235
Helical: 236-256
Cytoplasmic: 257-382
More Infomation

Liu, C., Wang, Y., Zhang, Y. H., Yuan, Z., Zhang, Z., Zeng, X., ... & Lu, S. (2023). Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status. Immunological Investigations, 52(7), 879-896.

Yang, Y., Chen, Z., Chu, X., Yan, Q., He, J., Guo, Y., ... & Pan, J. (2023). Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides. Matrix Biology, 117, 15-30.

Yang, B., Deng, B., Jiao, X. D., Qin, B. D., Lu, Y., Zhang, W., ... & Zang, Y. S. (2022). Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+ T cells. Cellular Oncology, 45(6), 1297-1309.

Li, L., Ma, H., & Song, C. (2022). LAYN acts as a prognostic biomarker in ovarian cancer by engaging T cell exclusion and dysfunction.

Cao, L., Zhu, L., & Cheng, L. (2022). ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis. BioMed Research International, 2022.

Mehta, P., Gouirand, V., Boda, D. P., Zhang, J., Gearty, S. V., Zirak, B., ... & Rosenblum, M. D. (2021). Layilin anchors regulatory T cells in skin. The Journal of Immunology, 207(7), 1763-1775.

Mahuron, K. M., Moreau, J. M., Glasgow, J. E., Boda, D. P., Pauli, M. L., Gouirand, V., ... & Rosenblum, M. D. (2020). Layilin augments integrin activation to promote antitumor immunity. Journal of Experimental Medicine, 217(9).

Pan, J. H., Zhou, H., Cooper, L., Huang, J. L., Zhu, S. B., Zhao, X. X., ... & Rong, L. (2019). LAYN is a prognostic biomarker and correlated with immune infiltrates in gastric and colon cancers. Frontiers in immunology, 10, 6.

Kim, Y., West, G. A., Ray, G., Kessler, S. P., Petrey, A. C., Fiocchi, C., ... & de la Motte, C. A. (2018). Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Matrix Biology, 66, 93-109.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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