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Rabbit Anti-KRT20 Recombinant Antibody (E19-I) (CBMAB-C0596-CN)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
E19-I
Application
IHC

Basic Information

Immunogen
Peptide corresponding to the C-Terminus of human cytokeratin 20
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
20 mM Tris-HCl, 20 mg/mL BSA, pH 8.0

Target

Full Name
Keratin 20
Introduction
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Entrez Gene ID
54474
UniProt ID
P35900
Alternative Names
Keratin 20; Keratin 20, Type I; Protein IT; CK-20; K20; Keratin, Type I Cytoskeletal 20; Cytokeratin 20;
Function
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cellular response to starvationIEA:Ensembl
Intermediate filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein secretionIEA:Ensembl
Cellular Location
Cytoplasm
PTM
Hyperphosphorylation at Ser-13 oCcurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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