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Mouse Anti-KLF10 Antibody (1D3) (CBMAB-0585-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D3
Antibody Isotype
IgG2a
Application
ChIP, IP, WB, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
KLF10
Introduction
KLF10 (kruppel like factor 10) is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. KLF10 is a member of a family of proteins that feature C2H2-type zinc finger domains. KLF10 may inhibit the growth of cancers, particularly pancreatic cancer.
Entrez Gene ID
7071
UniProt ID
Q13118
Alternative Names
EGRA; TIEG; TIEG1; EGR-alpha
Function
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity).
May play a role in the cell cycle regulation.
Biological Process
Bone mineralizationIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to starvationISS:UniProtKB
Circadian rhythmIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Somatic stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
More Infomation

Luo, H. Y., Zhu, J. Y., Chen, M., Mu, W. J., & Guo, L. (2023). Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes. Genes & Diseases, 10(3), 915-930.

Memon, A., Pyao, Y., Jung, Y., Choi, H. S., Song, K. D., & Lee, W. K. (2021). The basal transcriptional activity of the murine Klf10 gene is regulated by the transcriptional factor JunB. Genes & Genomics, 43, 343-349.

You, M., Zhang, L., Zhang, X., Fu, Y., & Dong, X. (2021). MicroRNA-197-3p inhibits the osteogenic differentiation in osteoporosis by down-regulating KLF 10. Clinical Interventions in Aging, 107-117.

Lee, J., Oh, A. R., Lee, H. Y., Moon, Y. A., Lee, H. J., & Cha, J. Y. (2020). Deletion of KLF10 leads to stress-induced liver fibrosis upon high sucrose feeding. International Journal of Molecular Sciences, 22(1), 331.

Lin, C. L., Hsu, Y. C., Huang, Y. T., Shih, Y. H., Wang, C. J., Chiang, W. C., & Chang, P. J. (2019). A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO molecular medicine, 11(5), e9828.

DiMario, J. X. (2018). KLF10 gene expression modulates fibrosis in dystrophic skeletal muscle. The American journal of pathology, 188(5), 1263-1275.

Liu, Y., Peng, W. Q., Guo, Y. Y., Liu, Y., Tang, Q. Q., & Guo, L. (2018). Krüppel-like factor 10 (KLF10) is transactivated by the transcription factor C/EBPβ and involved in early 3T3-L1 preadipocyte differentiation. Journal of Biological Chemistry, 293(36), 14012-14021.

Memon, A., & Lee, W. K. (2018). KLF10 as a tumor suppressor gene and its TGF-β signaling. Cancers, 10(6), 161.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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