Mouse Anti-KIF3A Monoclonal Antibody (K2.4) (CBMAB-1370-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Sea urchin, Rat, Frog

Clone

K2.4

Antibody Isotype

IgG1

Application

Blocking, ICC, IF, WB

Basic Information

Immunogen

Full length native protein (purified)- kinesin II purified from unfertilized sea urchin egg cytosol.

Specificity

Sea urchin, Rat, Frog

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Kinesin Family Member 3A

Introduction

KIF3A is microtubule-based anterograde translocator for membranous organelles. KIF3A has plus end-directed microtubule sliding activity in vitro.

Entrez Gene ID

Frog	120932325
Rat	84392

UniProt ID

Frog	F7B3N7
Rat	Q9WV62

Alternative Names

kinesin-like protein KIF3A

Function

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Biological Process

Anterograde axonal transportManual Assertion Based On ExperimentIBA:GO_Central
Centriole-centriole cohesionISS:UniProtKB
Cilium assemblyISS:UniProtKB
Microtubule anchoring at centrosomeISS:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Organelle organizationManual Assertion Based On ExperimentTAS:ProtInc
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Protein localization to cell junctionManual Assertion Based On ExperimentIMP:BHF-UCL
Protein transportManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, cilium; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to the subdistal appendage region of the centriole.

More Infomation

References

Liu, S., He, Y., Li, S., Gao, X., & Yang, F. (2023). Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway. Science Progress, 106(1), 00368504221148340.

Zhou, Q., Yu, J., Zheng, Q., Wu, T., Ji, Z., & Zhuo, Y. (2021). Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo. FEBS open bio, 11(5), 1487-1496.

Gailey, C. D., Wang, E. J., Jin, L., Ahmadi, S., Brautigan, D. L., Li, X., ... & Fu, Z. (2021). Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function. Developmental Dynamics, 250(2), 263-273.

Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., & Qu, Y. (2020). Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival. Oncology letters, 20(6), 1-1.

Xia, P., Chu, S., Liu, G., Chen, G., Yi, T., Feng, S., & Zhou, H. (2018). High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer. Biomedical Reports, 8(4), 343-349.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-KIF3A Recombinant Antibody (28/KIF3A)

Rabbit Anti-KIF3A Recombinant Antibody (CBLY1-086)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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