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Mouse Anti-KIF21B Monoclonal Antibody (4C12) (CBMAB-1369-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein KIF21B (XP_371332, aa 1183-1282) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
kinesin family member 21B
Introduction
KIF21B is a member of the kinesin superfamily which are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. KIF21B are associated with inflammatory bowel disease and multiple sclerosis.
Entrez Gene ID
23046
UniProt ID
O75037
Alternative Names
kinesin-like protein KIF21B
Function
Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Biological Process
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton; Cell projection, dendrite; Cell projection, growth cone; Cell projection, axon; Cytoplasmic vesicle
More Infomation

Ganchala, D., Pinto-Benito, D., Baides, E., Ruiz-Palmero, I., Grassi, D., & Arevalo, M. A. (2023). Kif21B mediates the effect of estradiol on the morphological plasticity of mouse hippocampal neurons. Frontiers in Molecular Neuroscience, 16, 1143024.

Narayanan, D. L., Rivera Alvarez, J., Tilly, P., Do Rosario, M. C., Bhat, V., Godin, J. D., & Shukla, A. (2022). Further delineation of KIF21B-related neurodevelopmental disorders. Journal of Human Genetics, 67(12), 729-733.

Xu, S., Li, Y., Huang, H., Miao, X., & Gu, Y. (2022). Identification of KIF21B as a Biomarker for Colorectal Cancer and Associated with Poor Prognosis. Journal of Oncology, 2022.

Ni, S., Li, J., Qiu, S., Xie, Y., Gong, K., & Duan, Y. (2021). KIF21B expression in osteosarcoma and its regulatory effect on osteosarcoma cell proliferation and apoptosis through the PI3K/AKT pathway. Frontiers in Oncology, 10, 606765.

Zhao, H. Q., Dong, B. L., Zhang, M., Dong, X. H., He, Y., Chen, S. Y., ... & Yang, X. J. (2020). Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma. World journal of gastrointestinal oncology, 12(3), 276.

Asselin, L., Rivera Alvarez, J., Heide, S., Bonnet, C. S., Tilly, P., Vitet, H., ... & Godin, J. D. (2020). Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity. Nature communications, 11(1), 2441.

Hooikaas, P. J., Damstra, H. G., Gros, O. J., van Riel, W. E., Martin, M., Smits, Y. T., ... & Akhmanova, A. (2020). Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells. Elife, 9, e62876.

Swarnkar, S., Avchalumov, Y., Raveendra, B. L., Grinman, E., & Puthanveettil, S. V. (2018). Kinesin family of proteins Kif11 and Kif21B act as inhibitory constraints of excitatory synaptic transmission through distinct mechanisms. Scientific Reports, 8(1), 17419.

Morikawa, M., Tanaka, Y., Cho, H. S., Yoshihara, M., & Hirokawa, N. (2018). The molecular motor KIF21B mediates synaptic plasticity and fear extinction by terminating Rac1 activation. Cell reports, 23(13), 3864-3877.

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For research use only. Not intended for any clinical use.

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