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Mouse Anti-KIF11 Recombinant Antibody (A757) (CBMAB-AP4154LY)


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Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Human, Mouse, Pig, Rat
Clone
A757
Antibody Isotype
IgG
Application
ELISA, ICC, WB

Basic Information

Immunogen
Purified recombinant human KIF11 protein fragments expressed in E.coli.
Specificity
Cattle, Dog, Human, Mouse, Pig, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Family Member 11
Introduction
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3832
Mouse16551
Rat171304
Dog477769
Pig100526080
Cattle508467
UniProt ID
HumanP52732
MouseQ6P9P6
RatF1MAB8
DogE2QXT6
PigF1SC89
CattleE1BF29
Alternative Names
Kinesin Family Member 11; Thyroid Receptor-Interacting Protein 5; Kinesin-Like Spindle Protein HKSP; Kinesin-Related Motor Protein Eg5; TR-Interacting Protein 5; Kinesin-Like Protein 1; TRIP-5; KNSL1;
Function
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501).
Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
Biological Process
Cell divisionIEA:UniProtKB-KW
Microtubule-based movementIEA:InterPro
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Mitotic centrosome separationIEA:Ensembl
Mitotic spindle assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of mitotic centrosome separationManual Assertion Based On ExperimentIMP:UniProtKB
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm; Cytoplasm, cytoskeleton, spindle pole
Involvement in disease
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR):
An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.
PTM
Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
More Infomation

Zhang, J., Wei, Z., Qi, X., Jiang, Y., Liu, D., & Liu, K. (2023). Kinesin family member 11 promotes progression of hepatocellular carcinoma via the OCT4 pathway. Functional & Integrative Genomics, 23(3), 284.

Ling, J., Wang, Y., Ma, L., Zheng, Y., Tang, H., Meng, L., & Zhang, L. (2022). KIF11, a plus end-directed kinesin, as a key gene in benzo (a) pyrene-induced non-small cell lung cancer. Environmental Toxicology and Pharmacology, 89, 103775.

Liu, J., Tian, Y., Yi, L., Gao, Z., Lou, M., & Yuan, K. (2022). High KIF11 expression is associated with poor outcome of NSCLC. Tumori Journal, 108(1), 40-46.

Wang, Y., Smallwood, P. M., Williams, J., & Nathans, J. (2020). A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Human molecular genetics, 29(7), 1121-1131.

Wang, B., Yu, J., Sun, Z., Luh, F., Lin, D., Shen, Y., ... & Liu, X. (2020). Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer. Molecular Carcinogenesis, 59(8), 908-922.

Jin, Q., Dai, Y., Wang, Y., Zhang, S., & Liu, G. (2019). High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma. Journal of clinical pathology, 72(5), 354-362.

Pei, Y. Y., Li, G. C., Ran, J., Wan, X. H., Wei, F. X., & Wang, L. (2019). Kinesin family member 11 enhances the self-renewal ability of breast cancer cells by participating in the Wnt/β-catenin pathway. Journal of Breast Cancer, 22(4), 522-532.

Swarnkar, S., Avchalumov, Y., Raveendra, B. L., Grinman, E., & Puthanveettil, S. V. (2018). Kinesin family of proteins Kif11 and Kif21B act as inhibitory constraints of excitatory synaptic transmission through distinct mechanisms. Scientific Reports, 8(1), 17419.

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For research use only. Not intended for any clinical use.

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