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Mouse Anti-KDM4C Recombinant Antibody (CBYJL-035) (CBMAB-L0065-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-035
Antibody Isotype
IgG1
Application
WB, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human KDM4C expression vector.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
KDM4C
Introduction
Gene of KDM4C is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and can converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23081
UniProt ID
Q9H3R0
Alternative Names
Lysine Demethylase 4C; JmjC Domain-Containing Histone Demethylation Protein 3C; Gene Amplified In Squamous Cell Carcinoma 1 Protein; Jumonji Domain-Containing Protein 2C; Lysine (K)-Specific Demethylase 4C; Tudor Domain Containing 14C; JMJD2C; JHDM3C; GASC1
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Biological Process
Blastocyst formationIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of androgen receptor signaling pathwayTAS:Reactome
Regulation of stem cell differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Pan, H. C., Chen, Y. H., Fang, W. C., Wu, V. C., & Sun, C. Y. (2022). Essential roles of the histone demethylase KDM4C in renal development and acute kidney injury. International Journal of Molecular Sciences, 23(16), 9318.

Lin, C. Y., Wang, B. J., Fu, Y. K., Huo, C., Wang, Y. P., Chen, B. C., ... & Chuu, C. P. (2022). Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism. Clinical and Translational Medicine, 12(3).

Jie, X., Chen, Y., Zhao, Y., Yang, X., Xu, Y., Wang, J., ... & Wu, G. (2022). Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer. Journal for Immunotherapy of Cancer, 10(2).

Jie, X., Fong, W. P., Zhou, R., Zhao, Y., Zhao, Y., Meng, R., ... & Xu, S. (2021). USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription. Cell Death & Differentiation, 28(7), 2095-2111.

Wang, J., Li, Y., Wang, P., Han, G., Zhang, T., Chang, J., ... & Zhang, H. (2020). Leukemogenic chromatin alterations promote AML leukemia stem cells via a KDM4C-ALKBH5-AXL signaling axis. Cell stem cell, 27(1), 81-97.

Chen, Y., Fang, R., Yue, C., Chang, G., Li, P., Guo, Q., ... & Huang, S. (2020). Wnt-induced stabilization of KDM4C is required for Wnt/β-catenin target gene expression and glioblastoma tumorigenesis. Cancer research, 80(5), 1049-1063.

Kato, H., Kushima, I., Mori, D., Yoshimi, A., Aleksic, B., Nawa, Y., ... & Ozaki, N. (2020). Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder. Translational psychiatry, 10(1), 421.

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., ... & Chuu, C. P. (2019). Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc. Cancers, 11(11), 1785.

Hung, K. H., Woo, Y. H., Lin, I. Y., Liu, C. H., Wang, L. C., Chen, H. Y., ... & Lin, K. I. (2018). The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells. Nucleic Acids Research, 46(11), 5547-5560.

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For research use only. Not intended for any clinical use.

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