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Rabbit Anti-JUP Recombinant Antibody (CBLG1-3067) (CBMAB-G6152-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Dog, Human
Clone
CBLG1-3067
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Dog, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.905 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
junction plakoglobin
Introduction
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Entrez Gene ID
Human3728
Mouse16480
Rat81679
Dog480522
UniProt ID
HumanP14923
MouseQ02257
RatQ6P0K8
DogA0A140T8E6
Function
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationManual Assertion Based On ExperimentIMP:BHF-UCL
Cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to indole-3-methanolManual Assertion Based On ExperimentIDA:UniProtKB
Desmosome assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of mechanical stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Endothelial cell-cell adhesionISS:BHF-UCL
Negative regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of canonical Wnt signaling pathway1 PublicationIC:BHF-UCL
Positive regulation of cell-matrix adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein import into nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Skin developmentIEA:Ensembl
Cellular Location
Cell junction, adherens junction; Cell junction, desmosome; Cytoplasm, cytoskeleton; Membrane. Cytoplasmic in a soluble and membrane-associated form.
Involvement in disease
Naxos disease (NXD):
An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.
Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
PTM
May be phosphorylated by FER.
More Infomation

Zinkovsky, D., & Sood, M. R. (2023). Isolated JUP plakoglobin gene mutation with left ventricular fibrosis in familial arrhythmogenic right ventricular cardiomyopathy. Journal of Cardiovascular Electrophysiology.

Chen, K., Zeng, J., Sun, Y., Ouyang, W., Yu, G., Zhou, H., ... & Xu, H. (2021). Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Communications, 41(4), 316-332.

Spethmann, T., Böckelmann, L. C., Labitzky, V., Ahlers, A. K., Schröder‐Schwarz, J., Bonk, S., ... & Lange, T. (2021). Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets. Molecular Oncology, 15(7), 1956-1969.

Fang, J., Xiao, L., Zhang, Q., Peng, Y., Wang, Z., & Liu, Y. (2020). Junction plakoglobin, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion. Journal of Oral Pathology & Medicine, 49(1), 30-38.

Weiland, F., Lokman, N. A., Klingler-Hoffmann, M., Jobling, T., Stephens, A. N., Sundfeldt, K., ... & Oehler, M. K. (2020). Ovarian blood sampling identifies junction plakoglobin as a novel biomarker of early ovarian cancer. Frontiers in Oncology, 10, 1767.

Negoita, F., Vavakova, M., Saell, J., Laurencikiene, J., & Goeransson, O. (2020). JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. Cellular Signalling, 76, 109786.

Leick, K. M., Rodriguez, A. B., Melssen, M. M., Benamar, M., Lindsay, R. S., Eki, R., ... & Slingluff Jr, C. L. (2019). The barrier molecules junction plakoglobin, filaggrin, and dystonin play roles in melanoma growth and angiogenesis. Annals of surgery, 270(4), 712.

Liu, L., Chen, C., Li, Y., & Yu, R. (2019). Whole-exome sequencing identified a de novo mutation of junction plakoglobin (p. R577C) in a Chinese patient with arrhythmogenic right ventricular cardiomyopathy. BioMed Research International, 2019.

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For research use only. Not intended for any clinical use.

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