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Mouse Anti-JPH1 Recombinant Antibody (2E6) (CBMAB-0146-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E6
Antibody Isotype
IgG2a, Κ
Application
WB, IP, ELISA

Basic Information

Immunogen
JPH1 (amino acid 501-580) paratial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
junctophilin 1
Introduction
JPH1 (Junctophilin 1) encodes the protein which is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. An important paralog of this gene is JPH3.
Entrez Gene ID
56704
UniProt ID
Q9HDC5
Alternative Names
JP1; JP-1; CMT2K
Function
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Biological Process
Calcium ion transport into cytosolManual Assertion Based On ExperimentTAS:BHF-UCL
Muscle organ developmentIEA:Ensembl
Regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cell membrane; Endoplasmic reticulum membrane; Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity).
Topology
Cytoplasmic: 1-639
Helical: 640-660
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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