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Mouse Anti-JAG2 Recombinant Antibody (4F10) (CBMAB-0216-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F10
Antibody Isotype
IgG2a, Κ
Application
WB, IP, ELISA

Basic Information

Immunogen
JAG2 (amino acid 121-210) paratial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
JAG2
Introduction
JAG2 (Jagged 2) is a Protein Coding gene. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Diseases associated with JAG2 include Ossifying Fibroma and Shipyard Eye. An important paralog of this gene is JAG1.
Entrez Gene ID
3714
UniProt ID
Q9Y219
Alternative Names
HJ2; SER2
Function
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
Biological Process
Auditory receptor cell fate commitmentBy SimilarityISS:UniProtKB
Cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Epithelial cell apoptotic process involved in palatal shelf morphogenesisIEA:Ensembl
Gamma-delta T cell differentiationIEA:Ensembl
In utero embryonic developmentIEA:Ensembl
Morphogenesis of embryonic epitheliumIEA:Ensembl
Notch signaling pathway1 PublicationNAS:UniProtKB
Odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of Notch signaling pathwayISS:UniProtKB
Regulation of cell adhesionIEA:Ensembl
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory system processIEA:Ensembl
Skeletal system developmentIEA:Ensembl
SpermatogenesisManual Assertion Based On ExperimentIEP:UniProtKB
T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Thymic T cell selectionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 27-1080
Helical: 1081-1101
Cytoplasmic: 1102-1238
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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