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Armenian Hamster Anti-ITGAX Recombinant Antibody (CBXC-3148) (CBMAB-C0399-CQ)


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Summary

Host Animal
Armenian Hamster
Specificity
Mouse
Clone
CBXC-3148
Antibody Isotype
IgG2
Application
FC, IHC, IP, IHC-P, CyTOF

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Subunit Alpha X
Introduction
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
16411
UniProt ID
Q9QXH4
Alternative Names
Integrin Subunit Alpha X
Function
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to virusIEA:Ensembl
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of endothelial tube morphogenesisManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of myelinationISS:ARUK-UCL
Cellular Location
Membrane
Topology
Extracellular: 20-1107
Helical: 1108-1128
Cytoplasmic: 1129-1163
More Infomation

Wang, X., Guan, Z., Tang, W., Wang, X., Xu, C., Shan, E., ... & Gao, Y. (2023). PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway. DNA and Cell Biology, 42(2), 97-104.

Ni, L., Li, P., Li, M., Huang, S., & Dang, N. (2023). SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells. Experimental Dermatology, 32(1), 24-29.

Lopes, K. D. P., Yu, L., Shen, X., Qiu, Y., Tasaki, S., Iatrou, A., ... & Bennett, D. A. (2023). Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults. Alzheimer's & Dementia.

Yan, S., Meng, L., Guo, X., Chen, Z., Zhang, Y., & Li, Y. (2022). Identification of ITGAX and CCR1 as potential biomarkers of atherosclerosis via gene set enrichment analysis. Journal of International Medical Research, 50(3), 03000605211039480.

Wang, J., Tai, Z., Yu, C., & Xu, Z. (2022). Serum exosome-mediated expression of ITGAX in hippocampus as a novel mechanism of blood-brain barrier dysfunction in epilepsy.

Sui, Y., Lu, K., & Fu, L. (2021). Prediction and analysis of novel key genes ITGAX, LAPTM5, SERPINE1 in clear cell renal cell carcinoma through bioinformatics analysis. PeerJ, 9, e11272.

Yang, H. Y., & Mao, T. N. (2021, May). ITGAX: A Potential Biomarker of Acute Myeloid Leukemia (AML) through Bioinformatic Analysis. In 2021 IEEE 9th International Conference on Bioinformatics and Computational Biology (ICBCB) (pp. 102-106). IEEE.

Shi, D., Zhong, Z., Xu, R., Li, B., Li, J., Habib, U., ... & Li, M. (2019). Association of ITGAX and ITGAM gene polymorphisms with susceptibility to IgA nephropathy. Journal of Human Genetics, 64(9), 927-935.

Gu, W., Sun, H., Zhang, M., Mo, S., Tan, C., Ni, S., ... & Wang, L. (2023). ITGB1 as a prognostic biomarker correlated with immune suppression in gastric cancer. Cancer Medicine, 12(2), 1520-1531.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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