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Rabbit Anti-ITGAV (phospho Y783) Recombinant Antibody (BA0071) (CBMAB-0415CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0071
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from Human Integrin beta 1 (phospho Y783)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Integrins serve as major receptors for extracellular matrix (ECM)-mediated cell adhesion and migration, cytoskeletal organization, cell proliferation, survival, and differentiation. Alpha-V integrins comprise a subset sharing a common alpha-V subunit combined with 1 of 5 beta subunits. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. The gene contains 30 exons and spans over 93 kb of genomic DNA. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Entrez Gene ID
3685
UniProt ID
P06756
Alternative Names
CD51; MSK8; VNRA; VTNR
More Infomation

Huang, S. W., Luo, J. Y., Qin, L. T., Huang, S. N., Huang, Z. G., Dang, Y. W., ... & Chen, G. (2022). Upregulation of ITGAV and the underlying mechanisms in nasopharyngeal carcinoma. Electronic Journal of Biotechnology, 60, 43-57.

Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S., ... & Ohtsuka, M. (2022). Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncology Reports, 47(5), 1-20.

Huang, J. M., Pang, Z. Y., Qi, G. B., Wang, Z., & Lv, Z. T. (2020). Association of ITGAV polymorphisms and risk of rheumatoid arthritis: evidence from a meta-analysis. Expert Review of Clinical Immunology, 16(6), 631-639.

Weiler, S. M., Lutz, T., Bissinger, M., Sticht, C., Knaub, M., Gretz, N., ... & Breuhahn, K. (2020). TAZ target gene ITGAV regulates invasion and feeds back positively on YAP and TAZ in liver cancer cells. Cancer Letters, 473, 164-175.

Cheuk, I. W. Y., Siu, M. T., Ho, J. C. W., Chen, J., Shin, V. Y., & Kwong, A. (2020). ITGAV targeting as a therapeutic approach for treatment of metastatic breast cancer. American journal of cancer research, 10(1), 211.

Loeser, H., Scholz, M., Fuchs, H., Essakly, A., Damanakis, A. I., Zander, T., ... & Gebauer, F. (2020). Integrin alpha V (ITGAV) expression in esophageal adenocarcinoma is associated with shortened overall-survival. Scientific Reports, 10(1), 18411.

Kang, C. L., Qi, B., Cai, Q. Q., Fu, L. S., Yang, Y., Tang, C., ... & Wu, X. Z. (2019). LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription. Theranostics, 9(15), 4421.

Lee, Y. S., Kim, K. C., Mongre, R. K., Kim, J. Y., Kim, Y. R., Choi, D. Y., ... & Hong, J. T. (2019). IL-32γ suppresses lung cancer stem cell growth via inhibition of ITGAV-mediated STAT5 pathway. Cell Death & Disease, 10(7), 506.

Lee, Y. S., Lee, C. H., Bae, J. T., Nam, K. T., Moon, D. B., Hwang, O. K., ... & Hong, J. T. (2018). Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition. Journal of Experimental & Clinical Cancer Research, 37, 1-16.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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